Sippl W - Search Results

1

Continuous Histone Deacylase Activity Assays.

Zessin M, Meleshin M, Sippl W, Schutkowski M. Zessin M, et al. Among authors: sippl w. Methods Mol Biol. 2023;2589:411-428. doi: 10.1007/978-1-0716-2788-4_27. Methods Mol Biol. 2023. PMID: 36255640

2

Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

Lawson M, Uciechowska U, Schemies J, Rumpf T, Jung M, Sippl W. Lawson M, et al. Among authors: sippl w. Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):726-39. doi: 10.1016/j.bbagrm.2010.06.003. Epub 2010 Jun 23. Biochim Biophys Acta. 2010. PMID: 20601279 Review.

3

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M. Stolfa DA, et al. Among authors: sippl w. J Mol Biol. 2014 Oct 9;426(20):3442-53. doi: 10.1016/j.jmb.2014.03.007. Epub 2014 Mar 20. J Mol Biol. 2014. PMID: 24657767 Free article.

4

Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors.

Roessler C, Nowak T, Pannek M, Gertz M, Nguyen GT, Scharfe M, Born I, Sippl W, Steegborn C, Schutkowski M. Roessler C, et al. Among authors: sippl w. Angew Chem Int Ed Engl. 2014 Sep 26;53(40):10728-32. doi: 10.1002/anie.201402679. Epub 2014 Aug 11. Angew Chem Int Ed Engl. 2014. PMID: 25111069

5

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M. Rumpf T, et al. Among authors: sippl w. Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263. Nat Commun. 2015. PMID: 25672491 Free PMC article.

6

Identification of peptidic substrates for the human kinase Myt1 using peptide microarrays.

Rohe A, Platzer C, Masch A, Greiner S, Henze C, Ihling C, Erdmann F, Schutkowski M, Sippl W, Schmidt M. Rohe A, et al. Among authors: sippl w. Bioorg Med Chem. 2015 Aug 1;23(15):4936-4942. doi: 10.1016/j.bmc.2015.05.021. Epub 2015 May 19. Bioorg Med Chem. 2015. PMID: 26059593

7

KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases.

Simon RP, Robaa D, Alhalabi Z, Sippl W, Jung M. Simon RP, et al. Among authors: sippl w. J Med Chem. 2016 Feb 25;59(4):1249-70. doi: 10.1021/acs.jmedchem.5b01502. Epub 2016 Jan 7. J Med Chem. 2016. PMID: 26701186 Review.

8

The Current State of NAD⁺ -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.

Schiedel M, Robaa D, Rumpf T, Sippl W, Jung M. Schiedel M, et al. Among authors: sippl w. Med Res Rev. 2018 Jan;38(1):147-200. doi: 10.1002/med.21436. Epub 2017 Jan 17. Med Res Rev. 2018. PMID: 28094444 Review.

9

Potent and Selective Inhibitors of Human Sirtuin 5.

Kalbas D, Liebscher S, Nowak T, Meleshin M, Pannek M, Popp C, Alhalabi Z, Bordusa F, Sippl W, Steegborn C, Schutkowski M. Kalbas D, et al. Among authors: sippl w. J Med Chem. 2018 Mar 22;61(6):2460-2471. doi: 10.1021/acs.jmedchem.7b01648. Epub 2018 Mar 12. J Med Chem. 2018. PMID: 29494161

10

New chemical tools for probing activity and inhibition of the NAD⁺-dependent lysine deacylase sirtuin 2.

Swyter S, Schiedel M, Monaldi D, Szunyogh S, Lehotzky A, Rumpf T, Ovádi J, Sippl W, Jung M. Swyter S, et al. Among authors: sippl w. Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170083. doi: 10.1098/rstb.2017.0083. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29685963 Free PMC article.

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