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Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance.
Cell Rep Med. 2023 Jan 17;4(1):100879. doi: 10.1016/j.xcrm.2022.100879. Epub 2023 Jan 3.
Cell Rep Med. 2023.
PMID: 36599351
Free PMC article.
Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets.
Sintov E, Nikolskiy I, Barrera V, Hyoje-Ryu Kenty J, Atkin AS, Gerace D, Ho Sui SJ, Boulanger K, Melton DA.
Sintov E, et al.
Stem Cell Reports. 2022 Sep 13;17(9):1976-1990. doi: 10.1016/j.stemcr.2022.08.002. Epub 2022 Sep 1.
Stem Cell Reports. 2022.
PMID: 36055241
Free PMC article.
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A human ESC line for efficient CRISPR editing of pluripotent stem cells.
Sintov E, Gerace D, Melton DA.
Sintov E, et al.
Stem Cell Res. 2021 Dec;57:102591. doi: 10.1016/j.scr.2021.102591. Epub 2021 Nov 2.
Stem Cell Res. 2021.
PMID: 34741877
Free article.
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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells.
Leite NC, Sintov E, Meissner TB, Brehm MA, Greiner DL, Harlan DM, Melton DA.
Leite NC, et al. Among authors: sintov e.
Cell Rep. 2020 Jul 14;32(2):107894. doi: 10.1016/j.celrep.2020.107894.
Cell Rep. 2020.
PMID: 32668238
Free PMC article.
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Charting cellular identity during human in vitro β-cell differentiation.
Veres A, Faust AL, Bushnell HL, Engquist EN, Kenty JH, Harb G, Poh YC, Sintov E, Gürtler M, Pagliuca FW, Peterson QP, Melton DA.
Veres A, et al. Among authors: sintov e.
Nature. 2019 May;569(7756):368-373. doi: 10.1038/s41586-019-1168-5. Epub 2019 May 8.
Nature. 2019.
PMID: 31068696
Free PMC article.
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Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro.
Sintov E, Nathan G, Knoller S, Pasmanik-Chor M, Russ HA, Efrat S.
Sintov E, et al.
Sci Rep. 2015 Aug 12;5:13024. doi: 10.1038/srep13024.
Sci Rep. 2015.
PMID: 26264186
Free PMC article.
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Redifferentiation of expanded human pancreatic β-cell-derived cells by inhibition of the NOTCH pathway.
Bar Y, Russ HA, Sintov E, Anker-Kitai L, Knoller S, Efrat S.
Bar Y, et al. Among authors: sintov e.
J Biol Chem. 2012 May 18;287(21):17269-17280. doi: 10.1074/jbc.M111.319152. Epub 2012 Mar 28.
J Biol Chem. 2012.
PMID: 22457355
Free PMC article.
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Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro.
Russ HA, Sintov E, Anker-Kitai L, Friedman O, Lenz A, Toren G, Farhy C, Pasmanik-Chor M, Oron-Karni V, Ravassard P, Efrat S.
Russ HA, et al. Among authors: sintov e.
PLoS One. 2011;6(9):e25566. doi: 10.1371/journal.pone.0025566. Epub 2011 Sep 30.
PLoS One. 2011.
PMID: 21984932
Free PMC article.
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