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Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.
Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW, Greenbaum DC. Love MS, et al. Among authors: sinnis p. Cell Host Microbe. 2012 Dec 13;12(6):815-23. doi: 10.1016/j.chom.2012.10.017. Cell Host Microbe. 2012. PMID: 23245326 Free PMC article.
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, Sidhu AB, Purcell LA, Gratraud P, Kremer L, Waters AP, Schiehser G, Jacobus DP, Janse CJ, Ager A, Jacobs WR Jr, Sacchettini JC, Heussler V, Sinnis P, Fidock DA. Yu M, et al. Among authors: sinnis p. Cell Host Microbe. 2008 Dec 11;4(6):567-78. doi: 10.1016/j.chom.2008.11.001. Cell Host Microbe. 2008. PMID: 19064257 Free PMC article.
Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.
Hopp CS, Bennett BL, Mishra S, Lehmann C, Hanson KK, Lin JW, Rousseau K, Carvalho FA, van der Linden WA, Santos NC, Bogyo M, Khan SM, Heussler V, Sinnis P. Hopp CS, et al. Among authors: sinnis p. PLoS Pathog. 2017 Sep 18;13(9):e1006586. doi: 10.1371/journal.ppat.1006586. eCollection 2017 Sep. PLoS Pathog. 2017. PMID: 28922424 Free PMC article.
110 results