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AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MY, Horowitz R, Ye P, Mathys H, Wang M, Niu X, Mazutis L, Jiang X, Wang X, Gao F, Brendel M, Telpoukhovskaia M, Tracy TE, Frost G, Zhou Y, Li Y, Qiu Y, Cheng Z, Yu G, Hardy J, Coppola G, Wang F, DeTure MA, Zhang B, Xie L, Trajnowski JQ, Lee VMY, Gong S, Sinha SC, Dickson DW, Luo W, Gan L. Sayed FA, et al. Among authors: sinha sc. Sci Transl Med. 2021 Dec;13(622):eabe3947. doi: 10.1126/scitranslmed.abe3947. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851693 Free PMC article.
A Pentacyclic Triterpene from Ligustrum lucidum Targets γ-Secretase.
Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V, Greengard P, Li YM, Sinha SC, Ip NY. Luo W, et al. Among authors: sinha a, sinha sc. ACS Chem Neurosci. 2020 Sep 16;11(18):2827-2835. doi: 10.1021/acschemneuro.0c00389. Epub 2020 Sep 3. ACS Chem Neurosci. 2020. PMID: 32786303 Free PMC article.
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
Carling GK, Fan L, Foxe NR, Norman K, Ye P, Wong MY, Zhu D, Yu F, Xu J, Yarahmady A, Chen H, Huang Y, Amin S, Zacharioudakis E, Chen X, Holtzman DM, Mok SA, Gavathiotis E, Sinha SC, Cheng F, Luo W, Gong S, Gan L. Carling GK, et al. Among authors: sinha sc. bioRxiv [Preprint]. 2024 Jan 25:2024.01.24.577107. doi: 10.1101/2024.01.24.577107. bioRxiv. 2024. PMID: 38328219 Free PMC article. Preprint.
Bidirectional regulation of Aβ levels by Presenilin 1.
Bustos V, Pulina MV, Kelahmetoglu Y, Sinha SC, Gorelick FS, Flajolet M, Greengard P. Bustos V, et al. Among authors: sinha sc. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7142-7147. doi: 10.1073/pnas.1705235114. Epub 2017 May 22. Proc Natl Acad Sci U S A. 2017. PMID: 28533411 Free PMC article.
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.
Kumar S, Singh SK, Viswakarma N, Sondarva G, Nair RS, Sethupathi P, Sinha SC, Emmadi R, Hoskins K, Danciu O, Thatcher GRJ, Rana B, Rana A. Kumar S, et al. Among authors: sinha sc. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7961-7970. doi: 10.1073/pnas.1921325117. Epub 2020 Mar 24. Proc Natl Acad Sci U S A. 2020. PMID: 32209667 Free PMC article.
108 results