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Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects.
Lachmandas E, Eckold C, Böhme J, Koeken VACM, Marzuki MB, Blok B, Arts RJW, Chen J, Teng KWW, Ratter J, Smolders EJ, Van den Heuvel C, Stienstra R, Dockrell HM, Newell E, Netea MG, Singhal A, Cliff JM, Van Crevel R. Lachmandas E, et al. Among authors: singhal a. J Infect Dis. 2019 Jun 5;220(1):139-150. doi: 10.1093/infdis/jiz064. J Infect Dis. 2019. PMID: 30753544 Free PMC article.
Metformin as adjunct antituberculosis therapy.
Singhal A, Jie L, Kumar P, Hong GS, Leow MK, Paleja B, Tsenova L, Kurepina N, Chen J, Zolezzi F, Kreiswirth B, Poidinger M, Chee C, Kaplan G, Wang YT, De Libero G. Singhal A, et al. Sci Transl Med. 2014 Nov 19;6(263):263ra159. doi: 10.1126/scitranslmed.3009885. Sci Transl Med. 2014. PMID: 25411472
Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.
Cheng CY, Gutierrez NM, Marzuki MB, Lu X, Foreman TW, Paleja B, Lee B, Balachander A, Chen J, Tsenova L, Kurepina N, Teng KWW, West K, Mehra S, Zolezzi F, Poidinger M, Kreiswirth B, Kaushal D, Kornfeld H, Newell EW, Singhal A. Cheng CY, et al. Among authors: singhal a. Sci Immunol. 2017 Mar;2(9):eaaj1789. doi: 10.1126/sciimmunol.aaj1789. Epub 2017 Mar 24. Sci Immunol. 2017. PMID: 28707004 Free PMC article.
NLRP10 Enhances CD4+ T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release.
Vacca M, Böhme J, Zambetti LP, Khameneh HJ, Paleja BS, Laudisi F, Ho AWS, Neo K, Leong KWK, Marzuki M, Lee B, Poidinger M, Santambrogio L, Tsenova L, Zolezzi F, De Libero G, Singhal A, Mortellaro A. Vacca M, et al. Among authors: singhal a. Front Immunol. 2017 Nov 2;8:1462. doi: 10.3389/fimmu.2017.01462. eCollection 2017. Front Immunol. 2017. PMID: 29163529 Free PMC article.
Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits.
Böhme J, Martinez N, Li S, Lee A, Marzuki M, Tizazu AM, Ackart D, Frenkel JH, Todd A, Lachmandas E, Lum J, Shihui F, Ng TP, Lee B, Larbi A, Netea MG, Basaraba R, van Crevel R, Newell E, Kornfeld H, Singhal A. Böhme J, et al. Among authors: singhal a. Nat Commun. 2020 Oct 16;11(1):5225. doi: 10.1038/s41467-020-19095-z. Nat Commun. 2020. PMID: 33067434 Free PMC article.
CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function.
Rouers A, Appanna R, Chevrier M, Lum J, Lau MC, Tan L, Loy T, Tay A, Sethi R, Sathiakumar D, Kaur K, Böhme J, Leo YS, Renia L, Howland SW, Singhal A, Chen J, Fink K. Rouers A, et al. Among authors: singhal a. iScience. 2021 Apr 29;24(5):102482. doi: 10.1016/j.isci.2021.102482. eCollection 2021 May 21. iScience. 2021. PMID: 34113823 Free PMC article.
Gut-Evolved Candida albicans Induces Metabolic Changes in Neutrophils.
Reales-Calderon JA, Tso GHW, Tan ASM, Hor PX, Böhme J, Teng KWW, Newell EW, Singhal A, Pavelka N. Reales-Calderon JA, et al. Among authors: singhal a. Front Cell Infect Microbiol. 2021 Nov 22;11:743735. doi: 10.3389/fcimb.2021.743735. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34881192 Free PMC article.
1,351 results