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Cdk5 mediates rotational force-induced brain injury.
Umfress A, Chakraborti A, Priya Sudarsana Devi S, Adams R, Epstein D, Massicano A, Sorace A, Singh S, Iqbal Hossian M, Andrabi SA, Crossman DK, Kumar N, Shahid Mukhtar M, Luo H, Simpson C, Abell K, Stokes M, Wiederhold T, Rosen C, Lu H, Natarajan A, Bibb JA. Umfress A, et al. Among authors: singh s. Sci Rep. 2023 Feb 28;13(1):3394. doi: 10.1038/s41598-023-29322-4. Sci Rep. 2023. PMID: 36854738 Free PMC article.
Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior.
Umfress A, Singh S, Ryan KJ, Chakraborti A, Plattner F, Sonawane Y, Mallareddy JR, Acosta EP, Natarajan A, Bibb JA. Umfress A, et al. Among authors: singh s. Front Pharmacol. 2022 May 12;13:863762. doi: 10.3389/fphar.2022.863762. eCollection 2022. Front Pharmacol. 2022. PMID: 35645825 Free PMC article.
Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.
Harris R, Yang M, Schmidt C, Royet C, Singh S, Natarajan A, Morris M, Frezza C, Laman H. Harris R, et al. Among authors: singh s. J Cell Biol. 2022 Jul 4;221(7):e202203095. doi: 10.1083/jcb.202203095. Epub 2022 Jun 7. J Cell Biol. 2022. PMID: 35670764 Free PMC article.
Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy.
Sagar S, Singh S, Mallareddy JR, Sonawane YA, Napoleon JV, Rana S, Contreras JI, Rajesh C, Ezell EL, Kizhake S, Garrison JC, Radhakrishnan P, Natarajan A. Sagar S, et al. Among authors: singh s. Eur J Med Chem. 2021 Oct 15;222:113579. doi: 10.1016/j.ejmech.2021.113579. Epub 2021 May 30. Eur J Med Chem. 2021. PMID: 34098465 Free PMC article.
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