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Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma.
Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J. Singh S, et al. Sci Transl Med. 2022 Jul 13;14(653):eabq2096. doi: 10.1126/scitranslmed.abq2096. Epub 2022 Jul 13. Sci Transl Med. 2022. PMID: 35857643 Free PMC article.
17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma.
Singh S, Abu-Zaid A, Lin W, Low J, Abdolvahabi A, Jin H, Wu Q, Cooke B, Fang J, Bowling J, Vaithiyalingam S, Currier D, Yun MK, Fernando DM, Maier J, Tillman H, Bulsara P, Lu Z, Das S, Shelat A, Li Z, Young B, Lee R, Rankovic Z, Murphy AJ, White SW, Davidoff AM, Chen T, Yang J. Singh S, et al. iScience. 2020 Dec 28;24(1):101996. doi: 10.1016/j.isci.2020.101996. eCollection 2021 Jan 22. iScience. 2020. PMID: 33490904 Free PMC article.
Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models.
Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Singh S, et al. Among authors: singh r. Sci Adv. 2021 Nov 19;7(47):eabj5405. doi: 10.1126/sciadv.abj5405. Epub 2021 Nov 17. Sci Adv. 2021. PMID: 34788094 Free PMC article.
Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma.
Fang J, Singh S, Cheng C, Natarajan S, Sheppard H, Abu-Zaid A, Durbin AD, Lee HW, Wu Q, Steele J, Connelly JP, Jin H, Chen W, Fan Y, Pruett-Miller SM, Rehg JE, Koo SC, Santiago T, Emmons J, Cairo S, Wang R, Glazer ES, Murphy AJ, Chen T, Davidoff AM, Armengol C, Easton J, Chen X, Yang J. Fang J, et al. Among authors: singh s. Nat Commun. 2023 Jul 6;14(1):4003. doi: 10.1038/s41467-023-39717-6. Nat Commun. 2023. PMID: 37414763 Free PMC article.
Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor.
Jablonowski C, Quarni W, Singh S, Tan H, Bostanthirige DH, Jin H, Fang J, Chang TC, Finkelstein D, Cho JH, Hu D, Pagala V, Sakurada SM, Pruett-Miller SM, Wang R, Murphy A, Freeman K, Peng J, Davidoff AM, Wu G, Yang J. Jablonowski C, et al. Among authors: singh s. bioRxiv [Preprint]. 2023 Nov 20:2023.06.26.546606. doi: 10.1101/2023.06.26.546606. bioRxiv. 2023. PMID: 37425900 Free PMC article. Updated. Preprint.
A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics.
Lee HM, Wright WC, Pan M, Low J, Currier D, Fang J, Singh S, Nance S, Delahunty I, Kim Y, Chapple RH, Zhang Y, Liu X, Steele JA, Qi J, Pruett-Miller SM, Easton J, Chen T, Yang J, Durbin AD, Geeleher P. Lee HM, et al. Among authors: singh s. Nat Commun. 2023 Nov 13;14(1):7332. doi: 10.1038/s41467-023-43134-0. Nat Commun. 2023. PMID: 37957169 Free PMC article.
Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor.
Jablonowski CM, Quarni W, Singh S, Tan H, Bostanthirige DH, Jin H, Fang J, Chang TC, Finkelstein D, Cho JH, Hu D, Pagala V, Sakurada SM, Pruett-Miller SM, Wang R, Murphy A, Freeman K, Peng J, Davidoff AM, Wu G, Yang J. Jablonowski CM, et al. Among authors: singh s. Elife. 2024 Mar 15;12:RP90993. doi: 10.7554/eLife.90993. Elife. 2024. PMID: 38488852 Free PMC article.
Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma.
Abu-Zaid A, Fang J, Jin H, Singh S, Pichavaram P, Wu Q, Tillman H, Janke L, Rosikiewicz W, Xu B, Van De Velde LA, Guo Y, Li Y, Shendy NAM, Delahunty IM, Rankovic Z, Chen T, Chen X, Freeman KW, Hatley ME, Durbin AD, Murray PJ, Murphy AJ, Thomas PG, Davidoff AM, Yang J. Abu-Zaid A, et al. Among authors: singh s. Cell Rep Med. 2024 Mar 19;5(3):101468. doi: 10.1016/j.xcrm.2024.101468. Cell Rep Med. 2024. PMID: 38508144 Free PMC article.
RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity.
Singh S, Fang J, Jin H, Van de Velde LA, Wu Q, Cortes A, Morton CL, Woolard MA, Quarni W, Steele JA, Connelly JP, He L, Thorne R, Turner G, Confer T, Johnson M, Caufield WV, Freeman BB, Lockey T, Pruett-Miller SM, Wang R, Davidoff AM, Thomas PG, Yang J. Singh S, et al. bioRxiv [Preprint]. 2024 Mar 25:2024.03.21.586157. doi: 10.1101/2024.03.21.586157. bioRxiv. 2024. PMID: 38585889 Free PMC article. Preprint.
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