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Adaptive immunity induces mutualism between commensal eukaryotes.
Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. Ost KS, et al. Among authors: singh s. Nature. 2021 Aug;596(7870):114-118. doi: 10.1038/s41586-021-03722-w. Epub 2021 Jul 14. Nature. 2021. PMID: 34262174 Free PMC article.
Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis.
Alkhazraji S, Gebremariam T, Alqarihi A, Gu Y, Mamouei Z, Singh S, Wiederhold NP, Shaw KJ, Ibrahim AS. Alkhazraji S, et al. Among authors: singh s. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01735-19. doi: 10.1128/AAC.01735-19. Print 2020 Feb 21. Antimicrob Agents Chemother. 2020. PMID: 31818813 Free PMC article.
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris.
Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA Jr, Cuomo CA, Williams NS, Ibrahim AS, Edwards JE Jr, Andes DR, Nodwell JR, Brown LE, Whitesell L, Robbins N, Cowen LE. Iyer KR, et al. Among authors: singh s. Nat Commun. 2020 Dec 22;11(1):6429. doi: 10.1038/s41467-020-20183-3. Nat Commun. 2020. PMID: 33353950 Free PMC article.
Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis.
Soliman SSM, Baldin C, Gu Y, Singh S, Gebremariam T, Swidergall M, Alqarihi A, Youssef EG, Alkhazraji S, Pikoulas A, Perske C, Venkataramani V, Rich A, Bruno VM, Hotopp JD, Mantis NJ, Edwards JE Jr, Filler SG, Chamilos G, Vitetta ES, Ibrahim AS. Soliman SSM, et al. Among authors: singh s. Nat Microbiol. 2021 Mar;6(3):313-326. doi: 10.1038/s41564-020-00837-0. Epub 2021 Jan 18. Nat Microbiol. 2021. PMID: 33462434 Free PMC article.
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