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A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies.
Flisikowska T, Egli J, Flisikowski K, Stumbaum M, Küng E, Ebeling M, Schmucki R, Georges G, Singer T, Kurome M, Kessler B, Zakhartchenko V, Wolf E, Weber F, Schnieke A, Iglesias A. Flisikowska T, et al. Among authors: singer t. Nat Biomed Eng. 2022 Nov;6(11):1248-1256. doi: 10.1038/s41551-022-00921-2. Epub 2022 Sep 22. Nat Biomed Eng. 2022. PMID: 36138193 Free PMC article.
The immunogenicity of antibody aggregates in a novel transgenic mouse model.
Bessa J, Boeckle S, Beck H, Buckel T, Schlicht S, Ebeling M, Kiialainen A, Koulov A, Boll B, Weiser T, Singer T, Rolink AG, Iglesias A. Bessa J, et al. Among authors: singer t. Pharm Res. 2015 Jul;32(7):2344-59. doi: 10.1007/s11095-015-1627-0. Epub 2015 Jan 29. Pharm Res. 2015. PMID: 25630815
First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils.
Weber F, Breustedt D, Schlicht S, Meyer CA, Niewoehner J, Ebeling M, Freskgard PO, Bruenker P, Singer T, Reth M, Iglesias A. Weber F, et al. Among authors: singer t. Pharm Res. 2018 Jun 27;35(9):169. doi: 10.1007/s11095-018-2448-8. Pharm Res. 2018. PMID: 29951887 Free PMC article.
Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.
Drawnel FM, Zhang JD, Küng E, Aoyama N, Benmansour F, Araujo Del Rosario A, Jensen Zoffmann S, Delobel F, Prummer M, Weibel F, Carlson C, Anson B, Iacone R, Certa U, Singer T, Ebeling M, Prunotto M. Drawnel FM, et al. Among authors: singer t. Cell Chem Biol. 2017 May 18;24(5):624-634.e3. doi: 10.1016/j.chembiol.2017.03.016. Epub 2017 Apr 20. Cell Chem Biol. 2017. PMID: 28434878 Free article.
Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.
Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, Li J, McVay S, O'Mahony J, Otteneder M, Pantze M, Putnam WS, Qiu ZJ, Ruppel J, Singer T, Stauch O, Theil FP, Visich J, Yang J, Ying Y, Khawli LA, Richter WF. Zheng Y, et al. Among authors: singer t. MAbs. 2012 Mar-Apr;4(2):243-55. doi: 10.4161/mabs.4.2.19387. Epub 2012 Mar 1. MAbs. 2012. PMID: 22453096 Free PMC article.
675 results