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Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.
Drawnel FM, Zhang JD, Küng E, Aoyama N, Benmansour F, Araujo Del Rosario A, Jensen Zoffmann S, Delobel F, Prummer M, Weibel F, Carlson C, Anson B, Iacone R, Certa U, Singer T, Ebeling M, Prunotto M. Drawnel FM, et al. Among authors: singer t. Cell Chem Biol. 2017 May 18;24(5):624-634.e3. doi: 10.1016/j.chembiol.2017.03.016. Epub 2017 Apr 20. Cell Chem Biol. 2017. PMID: 28434878 Free article.
Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.
Moisan A, Gubler M, Zhang JD, Tessier Y, Dumong Erichsen K, Sewing S, Gérard R, Avignon B, Huber S, Benmansour F, Chen X, Villaseñor R, Braendli-Baiocco A, Festag M, Maunz A, Singer T, Schuler F, Roth AB. Moisan A, et al. Among authors: singer t. Mol Ther Nucleic Acids. 2017 Mar 17;6:89-105. doi: 10.1016/j.omtn.2016.11.006. Epub 2016 Dec 10. Mol Ther Nucleic Acids. 2017. PMID: 28325303 Free PMC article.
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies.
Flisikowska T, Egli J, Flisikowski K, Stumbaum M, Küng E, Ebeling M, Schmucki R, Georges G, Singer T, Kurome M, Kessler B, Zakhartchenko V, Wolf E, Weber F, Schnieke A, Iglesias A. Flisikowska T, et al. Among authors: singer t. Nat Biomed Eng. 2022 Nov;6(11):1248-1256. doi: 10.1038/s41551-022-00921-2. Epub 2022 Sep 22. Nat Biomed Eng. 2022. PMID: 36138193 Free PMC article.
The immunogenicity of antibody aggregates in a novel transgenic mouse model.
Bessa J, Boeckle S, Beck H, Buckel T, Schlicht S, Ebeling M, Kiialainen A, Koulov A, Boll B, Weiser T, Singer T, Rolink AG, Iglesias A. Bessa J, et al. Among authors: singer t. Pharm Res. 2015 Jul;32(7):2344-59. doi: 10.1007/s11095-015-1627-0. Epub 2015 Jan 29. Pharm Res. 2015. PMID: 25630815
675 results