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Lipid efflux mechanisms, relation to disease and potential therapeutic aspects.
Castaño D, Rattanasopa C, Monteiro-Cardoso VF, Corlianò M, Liu Y, Zhong S, Rusu M, Liehn EA, Singaraja RR. Castaño D, et al. Among authors: singaraja rr. Adv Drug Deliv Rev. 2020;159:54-93. doi: 10.1016/j.addr.2020.04.013. Epub 2020 May 11. Adv Drug Deliv Rev. 2020. PMID: 32423566 Review.
ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.
Trigueros-Motos L, van Capelleveen JC, Torta F, Castaño D, Zhang LH, Chai EC, Kang M, Dimova LG, Schimmel AWM, Tietjen I, Radomski C, Tan LJ, Thiam CH, Narayanaswamy P, Wu DH, Dorninger F, Yakala GK, Barhdadi A, Angeli V, Dubé MP, Berger J, Dallinga-Thie GM, Tietge UJF, Wenk MR, Hayden MR, Hovingh GK, Singaraja RR. Trigueros-Motos L, et al. Among authors: singaraja rr. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2147-2155. doi: 10.1161/ATVBAHA.117.309574. Epub 2017 Sep 7. Arterioscler Thromb Vasc Biol. 2017. PMID: 28882873
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.
Chevre R, Trigueros-Motos L, Castaño D, Chua T, Corlianò M, Patankar JV, Sng L, Sim L, Juin TL, Carissimo G, Ng LFP, Yi CNJ, Eliathamby CC, Groen AK, Hayden MR, Singaraja RR. Chevre R, et al. Among authors: singaraja rr. FASEB J. 2018 Jul;32(7):3792-3802. doi: 10.1096/fj.201701084RR. Epub 2018 Feb 26. FASEB J. 2018. PMID: 29481310
FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.
Yakala GK, Cabrera-Fuentes HA, Crespo-Avilan GE, Rattanasopa C, Burlacu A, George BL, Anand K, Mayan DC, Corlianò M, Hernández-Reséndiz S, Wu Z, Schwerk AMK, Tan ALJ, Trigueros-Motos L, Chèvre R, Chua T, Kleemann R, Liehn EA, Hausenloy DJ, Ghosh S, Singaraja RR. Yakala GK, et al. Among authors: singaraja rr. Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):387-401. doi: 10.1161/ATVBAHA.118.311903. Arterioscler Thromb Vasc Biol. 2019. PMID: 30651003 Free PMC article.
Bile Acids: A Communication Channel in the Gut-Brain Axis.
Monteiro-Cardoso VF, Corlianò M, Singaraja RR. Monteiro-Cardoso VF, et al. Among authors: singaraja rr. Neuromolecular Med. 2021 Mar;23(1):99-117. doi: 10.1007/s12017-020-08625-z. Epub 2020 Oct 21. Neuromolecular Med. 2021. PMID: 33085065 Review.
Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice.
Liu Y, Castano D, Girolamo F, Trigueros-Motos L, Bae HG, Neo SP, Oh J, Narayanaswamy P, Torta F, Rye KA, Jo DG, Gunaratne J, Jung S, Virgintino D, Singaraja RR. Liu Y, et al. Among authors: singaraja rr. J Lipid Res. 2022 Jan;63(1):100147. doi: 10.1016/j.jlr.2021.100147. Epub 2021 Nov 6. J Lipid Res. 2022. PMID: 34752805 Free PMC article.
Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy.
Tripathi M, Singh BK, Liehn EA, Lim SY, Tikno K, Castano-Mayan D, Rattanasopa C, Nilcham P, Abdul Ghani SAB, Wu Z, Azhar SH, Zhou J, Hernández-Resèndiz S, Crespo-Avilan GE, Sinha RA, Farah BL, Moe KT, De Silva DA, Angeli V, Singh MK, Singaraja RR, Hausenloy DJ, Yen PM. Tripathi M, et al. Among authors: singaraja rr. Autophagy. 2022 Sep;18(9):2150-2160. doi: 10.1080/15548627.2021.2021494. Epub 2022 Jan 11. Autophagy. 2022. PMID: 35012409 Free PMC article.
Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans.
Zhong S, Chèvre R, Castaño Mayan D, Corlianò M, Cochran BJ, Sem KP, van Dijk TH, Peng J, Tan LJ, Hartimath SV, Ramasamy B, Cheng P, Groen AK, Kuipers F, Goggi JL, Drum C, van Dam RM, Tan RS, Rye KA, Hayden MR, Cheng CY, Chacko S, Flannick J, Sim X, Tan HC, Singaraja RR. Zhong S, et al. Among authors: singaraja rr. J Clin Invest. 2022 Nov 1;132(21):e152961. doi: 10.1172/JCI152961. J Clin Invest. 2022. PMID: 36107630 Free PMC article.
Multiomics analyses reveal dynamic bioenergetic pathways and functional remodeling of the heart during intermittent fasting.
Arumugam TV, Alli-Shaik A, Liehn EA, Selvaraji S, Poh L, Rajeev V, Cho Y, Cho Y, Kim J, Kim J, Swa HLF, Hao DTZ, Rattanasopa C, Fann DY, Mayan DC, Ng GY, Baik SH, Mallilankaraman K, Gelderblom M, Drummond GR, Sobey CG, Kennedy BK, Singaraja RR, Mattson MP, Jo DG, Gunaratne J. Arumugam TV, et al. Among authors: singaraja rr. Elife. 2023 Sep 28;12:RP89214. doi: 10.7554/eLife.89214. Elife. 2023. PMID: 37769126 Free PMC article.
90 results