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The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X. Emmerson PJ, et al. Among authors: sindelar dk. Nat Med. 2017 Oct;23(10):1215-1219. doi: 10.1038/nm.4393. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846098
Synthesis and SAR of novel histamine H3 receptor antagonists.
Jesudason CD, Beavers LS, Cramer JW, Dill J, Finley DR, Lindsley CW, Stevens FC, Gadski RA, Oldham SW, Pickard RT, Siedem CS, Sindelar DK, Singh A, Watson BM, Hipskind PA. Jesudason CD, et al. Among authors: sindelar dk. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3415-8. doi: 10.1016/j.bmcl.2006.04.004. Epub 2006 May 3. Bioorg Med Chem Lett. 2006. PMID: 16677814
Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
Durham TB, Toth JL, Klimkowski VJ, Cao JX, Siesky AM, Alexander-Chacko J, Wu GY, Dixon JT, McGee JE, Wang Y, Guo SY, Cavitt RN, Schindler J, Thibodeaux SJ, Calvert NA, Coghlan MJ, Sindelar DK, Christe M, Kiselyov VV, Michael MD, Sloop KW. Durham TB, et al. Among authors: sindelar dk. J Biol Chem. 2015 Aug 14;290(33):20044-59. doi: 10.1074/jbc.M115.638205. Epub 2015 Jun 17. J Biol Chem. 2015. PMID: 26085101 Free PMC article.
35 results