Sinclair LV - Search Results

1

Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity.

Jenkins BJ, Blagih J, Ponce-Garcia FM, Canavan M, Gudgeon N, Eastham S, Hill D, Hanlon MM, Ma EH, Bishop EL, Rees A, Cronin JG, Jury EC, Dimeloe SK, Veale DJ, Thornton CA, Vousden KH, Finlay DK, Fearon U, Jones GW, Sinclair LV, Vincent EE, Jones N. Jenkins BJ, et al. Among authors: sinclair lv. Cell Metab. 2023 Jul 11;35(7):1132-1146.e9. doi: 10.1016/j.cmet.2023.05.001. Epub 2023 May 24. Cell Metab. 2023. PMID: 37230079 Free article.

2

Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation.

Waugh C, Sinclair L, Finlay D, Bayascas JR, Cantrell D. Waugh C, et al. Mol Cell Biol. 2009 Nov;29(21):5952-62. doi: 10.1128/MCB.00585-09. Epub 2009 Aug 24. Mol Cell Biol. 2009. PMID: 19703999 Free PMC article.

3

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes.

Finlay DK, Sinclair LV, Feijoo C, Waugh CM, Hagenbeek TJ, Spits H, Cantrell DA. Finlay DK, et al. Among authors: sinclair lv. J Exp Med. 2009 Oct 26;206(11):2441-54. doi: 10.1084/jem.20090219. Epub 2009 Oct 5. J Exp Med. 2009. PMID: 19808258 Free PMC article.

4

Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells.

Finlay DK, Kelly AP, Clarke R, Sinclair LV, Deak M, Alessi DR, Cantrell DA. Finlay DK, et al. Among authors: sinclair lv. J Immunol. 2010 Nov 15;185(10):5973-82. doi: 10.4049/jimmunol.1000827. Epub 2010 Oct 13. J Immunol. 2010. PMID: 20944007 Free PMC article.

5

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.

Macintyre AN, Finlay D, Preston G, Sinclair LV, Waugh CM, Tamas P, Feijoo C, Okkenhaug K, Cantrell DA. Macintyre AN, et al. Among authors: sinclair lv. Immunity. 2011 Feb 25;34(2):224-36. doi: 10.1016/j.immuni.2011.01.012. Epub 2011 Feb 3. Immunity. 2011. PMID: 21295499 Free PMC article.

6

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.

Finlay DK, Rosenzweig E, Sinclair LV, Feijoo-Carnero C, Hukelmann JL, Rolf J, Panteleyev AA, Okkenhaug K, Cantrell DA. Finlay DK, et al. Among authors: sinclair lv. J Exp Med. 2012 Dec 17;209(13):2441-53. doi: 10.1084/jem.20112607. Epub 2012 Nov 26. J Exp Med. 2012. PMID: 23183047 Free PMC article.

7

Nutrient sensing, signal transduction and immune responses.

Walls J, Sinclair L, Finlay D. Walls J, et al. Semin Immunol. 2016 Oct;28(5):396-407. doi: 10.1016/j.smim.2016.09.001. Epub 2016 Sep 24. Semin Immunol. 2016. PMID: 27681670 Review.

8

Glucose represses dendritic cell-induced T cell responses.

Lawless SJ, Kedia-Mehta N, Walls JF, McGarrigle R, Convery O, Sinclair LV, Navarro MN, Murray J, Finlay DK. Lawless SJ, et al. Among authors: sinclair lv. Nat Commun. 2017 May 30;8:15620. doi: 10.1038/ncomms15620. Nat Commun. 2017. PMID: 28555668 Free PMC article.

9

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice.

Loftus RM, Assmann N, Kedia-Mehta N, O'Brien KL, Garcia A, Gillespie C, Hukelmann JL, Oefner PJ, Lamond AI, Gardiner CM, Dettmer K, Cantrell DA, Sinclair LV, Finlay DK. Loftus RM, et al. Among authors: sinclair lv. Nat Commun. 2018 Jun 14;9(1):2341. doi: 10.1038/s41467-018-04719-2. Nat Commun. 2018. PMID: 29904050 Free PMC article.

10

Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses.

O'Brien A, Loftus RM, Pisarska MM, Tobin LM, Bergin R, Wood NAW, Foley C, Mat A, Tinley FC, Bannan C, Sommerville G, Veerapen N, Besra GS, Sinclair LV, Moynagh PN, Lynch L, Finlay DK, O'Shea D, Hogan AE. O'Brien A, et al. Among authors: sinclair lv. J Immunol. 2019 Jun 15;202(12):3404-3411. doi: 10.4049/jimmunol.1801600. Epub 2019 May 10. J Immunol. 2019. PMID: 31076528

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