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Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma.
Peat TJ, Gaikwad SM, Dubois W, Gyabaah-Kessie N, Zhang S, Gorjifard S, Phyo Z, Andres M, Hughitt VK, Simpson RM, Miller MA, Girvin AT, Taylor A, Williams D, D'Antonio N, Zhang Y, Rajagopalan A, Flietner E, Wilson K, Zhang X, Shinn P, Klumpp-Thomas C, McKnight C, Itkin Z, Chen L, Kazandijian D, Zhang J, Michalowski AM, Simmons JK, Keats J, Thomas CJ, Mock BA. Peat TJ, et al. Among authors: simpson rm. Cancer Lett. 2023 Aug 1;568:216284. doi: 10.1016/j.canlet.2023.216284. Epub 2023 Jun 24. Cancer Lett. 2023. PMID: 37356470
Hypomorphic mTOR Downregulates CDK6 and Delays Thymic Pre-T LBL Tumorigenesis.
Gary JM, Simmons JK, Xu J, Zhang S, Peat TJ, Watson N, Gamache BJ, Zhang K, Kovalchuk AL, Michalowski AM, Chen JQ, Thaiwong T, Kiupel M, Gaikwad S, Etienne M, Simpson RM, Dubois W, Testa JR, Mock BA. Gary JM, et al. Among authors: simpson rm. Mol Cancer Ther. 2020 Oct;19(10):2221-2232. doi: 10.1158/1535-7163.MCT-19-0671. Epub 2020 Aug 3. Mol Cancer Ther. 2020. PMID: 32747423 Free PMC article.
TORC1 and class I HDAC inhibitors synergize to suppress mature B cell neoplasms.
Simmons JK, Patel J, Michalowski A, Zhang S, Wei BR, Sullivan P, Gamache B, Felsenstein K, Kuehl WM, Simpson RM, Zingone A, Landgren O, Mock BA. Simmons JK, et al. Among authors: simpson rm. Mol Oncol. 2014 Mar;8(2):261-72. doi: 10.1016/j.molonc.2013.11.007. Epub 2013 Dec 3. Mol Oncol. 2014. PMID: 24429254 Free PMC article.
High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer.
Jansson KH, Tucker JB, Stahl LE, Simmons JK, Fuller C, Beshiri ML, Agarwal S, Fang L, Hynes PG, Alilin AN, Lake R, Abbey YC, Cawley J, Tice CM, Yin J, McKnight C, Klummp-Thomas C, Zhang X, Guha R, Hoover S, Simpson RM, Nguyen HM, Corey E, Thomas CJ, Proia DA, Kelly K. Jansson KH, et al. Among authors: simpson rm. Sci Rep. 2018 Nov 22;8(1):17239. doi: 10.1038/s41598-018-35417-0. Sci Rep. 2018. PMID: 30467317 Free PMC article.
B cell-specific deficiencies in mTOR limit humoral immune responses.
Zhang S, Pruitt M, Tran D, Du Bois W, Zhang K, Patel R, Hoover S, Simpson RM, Simmons J, Gary J, Snapper CM, Casellas R, Mock BA. Zhang S, et al. Among authors: simpson rm. J Immunol. 2013 Aug 15;191(4):1692-703. doi: 10.4049/jimmunol.1201767. Epub 2013 Jul 15. J Immunol. 2013. PMID: 23858034 Free PMC article.
Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment.
Barkan D, El Touny LH, Michalowski AM, Smith JA, Chu I, Davis AS, Webster JD, Hoover S, Simpson RM, Gauldie J, Green JE. Barkan D, et al. Among authors: simpson rm. Cancer Res. 2010 Jul 15;70(14):5706-16. doi: 10.1158/0008-5472.CAN-09-2356. Epub 2010 Jun 22. Cancer Res. 2010. PMID: 20570886 Free PMC article.
166 results