Simpson KJ - Search Results

1

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction.

Fujihara KM, Zhang BZ, Jackson TD, Ogunkola MO, Nijagal B, Milne JV, Sallman DA, Ang CS, Nikolic I, Kearney CJ, Hogg SJ, Cabalag CS, Sutton VR, Watt S, Fujihara AT, Trapani JA, Simpson KJ, Stojanovski D, Leimkühler S, Haupt S, Phillips WA, Clemons NJ. Fujihara KM, et al. Among authors: simpson kj. Sci Adv. 2022 Sep 16;8(37):eabm9427. doi: 10.1126/sciadv.abm9427. Epub 2022 Sep 14. Sci Adv. 2022. PMID: 36103522 Free PMC article.

2

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.

Brasacchio D, Noori T, House C, Brennan AJ, Simpson KJ, Susanto O, Bird PI, Johnstone RW, Trapani JA. Brasacchio D, et al. Among authors: simpson kj. Cell Death Differ. 2014 May;21(5):748-60. doi: 10.1038/cdd.2013.203. Epub 2014 Jan 24. Cell Death Differ. 2014. PMID: 24464226 Free PMC article.

3

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity.

Falkenberg KJ, Newbold A, Gould CM, Luu J, Trapani JA, Matthews GM, Simpson KJ, Johnstone RW. Falkenberg KJ, et al. Among authors: simpson kj. Cell Death Differ. 2016 Jul;23(7):1209-18. doi: 10.1038/cdd.2015.175. Epub 2016 Feb 12. Cell Death Differ. 2016. PMID: 26868908 Free PMC article.

4

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.

Brasacchio D, Alsop AE, Noori T, Lufti M, Iyer S, Simpson KJ, Bird PI, Kluck RM, Johnstone RW, Trapani JA. Brasacchio D, et al. Among authors: simpson kj. Cell Death Differ. 2017 Jun;24(6):961-970. doi: 10.1038/cdd.2016.119. Epub 2017 Jan 6. Cell Death Differ. 2017. PMID: 28060382 Free PMC article.

5

Discovering cancer vulnerabilities using high-throughput micro-RNA screening.

Nikolic I, Elsworth B, Dodson E, Wu SZ, Gould CM, Mestdagh P, Marshall GM, Horvath LG, Simpson KJ, Swarbrick A. Nikolic I, et al. Among authors: simpson kj. Nucleic Acids Res. 2017 Dec 15;45(22):12657-12670. doi: 10.1093/nar/gkx1072. Nucleic Acids Res. 2017. PMID: 29156009 Free PMC article.

6

A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens.

Cluse LA, Nikolic I, Knight D, Madhamshettiwar PB, Luu J, Cowley KJ, Semple T, Arnau GM, Shortt J, Johnstone RW, Simpson KJ. Cluse LA, et al. Among authors: simpson kj. Methods Mol Biol. 2018;1725:201-227. doi: 10.1007/978-1-4939-7568-6_17. Methods Mol Biol. 2018. PMID: 29322420

7

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA. Pearson HB, et al. Among authors: simpson kj. Cancer Discov. 2018 Jun;8(6):764-779. doi: 10.1158/2159-8290.CD-17-0867. Epub 2018 Mar 26. Cancer Discov. 2018. PMID: 29581176

8

MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer.

Lin HM, Nikolic I, Yang J, Castillo L, Deng N, Chan CL, Yeung NK, Dodson E, Elsworth B, Spielman C, Lee BY, Boyer Z, Simpson KJ, Daly RJ, Horvath LG, Swarbrick A. Lin HM, et al. Among authors: simpson kj. Sci Rep. 2018 May 18;8(1):7820. doi: 10.1038/s41598-018-26050-y. Sci Rep. 2018. PMID: 29777112 Free PMC article.

9

Requirement for cleavage factor II_m in the control of alternative polyadenylation in breast cancer cells.

Turner RE, Henneken LM, Liem-Weits M, Harrison PF, Swaminathan A, Vary R, Nikolic I, Simpson KJ, Powell DR, Beilharz TH, Dichtl B. Turner RE, et al. Among authors: simpson kj. RNA. 2020 Aug;26(8):969-981. doi: 10.1261/rna.075226.120. Epub 2020 Apr 15. RNA. 2020. PMID: 32295865 Free PMC article.

10

GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.

Gotovac JR, Liu DS, Yates MJ, Milne JV, Macpherson AA, Simpson KJ, Eslick GD, Mitchell C, Duong CP, Phillips WA, Clemons NJ. Gotovac JR, et al. Among authors: simpson kj. J Pathol. 2020 Nov;252(3):317-329. doi: 10.1002/path.5528. Epub 2020 Sep 15. J Pathol. 2020. PMID: 32737994 Free PMC article.

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