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Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis.
Kong IY, Trezise S, Light A, Todorovski I, Arnau GM, Gadipally S, Yoannidis D, Simpson KJ, Dong X, Whitehead L, Tempany JC, Farchione AJ, Sheikh AA, Groom JR, Rogers KL, Herold MJ, Bryant VL, Ritchie ME, Willis SN, Johnstone RW, Hodgkin PD, Nutt SL, Vervoort SJ, Hawkins ED. Kong IY, et al. Among authors: simpson kj. Cell Death Differ. 2022 Dec;29(12):2519-2530. doi: 10.1038/s41418-022-01037-5. Epub 2022 Jul 13. Cell Death Differ. 2022. PMID: 35831623 Free PMC article.
A functional genetic screen defines the AKT-induced senescence signaling network.
Chan KT, Blake S, Zhu H, Kang J, Trigos AS, Madhamshettiwar PB, Diesch J, Paavolainen L, Horvath P, Hannan RD, George AJ, Sanij E, Hannan KM, Simpson KJ, Pearson RB. Chan KT, et al. Among authors: simpson kj. Cell Death Differ. 2020 Feb;27(2):725-741. doi: 10.1038/s41418-019-0384-8. Epub 2019 Jul 8. Cell Death Differ. 2020. PMID: 31285545 Free PMC article.
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Vervoort SJ, Welsh SA, Devlin JR, Barbieri E, Knight DA, Offley S, Bjelosevic S, Costacurta M, Todorovski I, Kearney CJ, Sandow JJ, Fan Z, Blyth B, McLeod V, Vissers JHA, Pavic K, Martin BP, Gregory G, Demosthenous E, Zethoven M, Kong IY, Hawkins ED, Hogg SJ, Kelly MJ, Newbold A, Simpson KJ, Kauko O, Harvey KF, Ohlmeyer M, Westermarck J, Gray N, Gardini A, Johnstone RW. Vervoort SJ, et al. Among authors: simpson kj. Cell. 2021 Jun 10;184(12):3143-3162.e32. doi: 10.1016/j.cell.2021.04.022. Epub 2021 May 17. Cell. 2021. PMID: 34004147 Free PMC article.
289 results