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TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.
Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ. Bird TG, et al. Among authors: simpson kj. Sci Transl Med. 2018 Aug 15;10(454):eaan1230. doi: 10.1126/scitranslmed.aan1230. Sci Transl Med. 2018. PMID: 30111642 Free PMC article.
Galectin-3 regulates myofibroblast activation and hepatic fibrosis.
Henderson NC, Mackinnon AC, Farnworth SL, Poirier F, Russo FP, Iredale JP, Haslett C, Simpson KJ, Sethi T. Henderson NC, et al. Among authors: simpson kj. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5060-5. doi: 10.1073/pnas.0511167103. Epub 2006 Mar 20. Proc Natl Acad Sci U S A. 2006. PMID: 16549783 Free PMC article.
Galectin-3 regulates hepatic progenitor cell expansion during liver injury.
Hsieh WC, Mackinnon AC, Lu WY, Jung J, Boulter L, Henderson NC, Simpson KJ, Schotanus B, Wojtacha D, Bird TG, Medine CN, Hay DC, Sethi T, Iredale JP, Forbes SJ. Hsieh WC, et al. Among authors: simpson kj. Gut. 2015 Feb;64(2):312-21. doi: 10.1136/gutjnl-2013-306290. Epub 2014 May 16. Gut. 2015. PMID: 24837171
CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure.
Stutchfield BM, Antoine DJ, Mackinnon AC, Gow DJ, Bain CC, Hawley CA, Hughes MJ, Francis B, Wojtacha D, Man TY, Dear JW, Devey LR, Mowat AM, Pollard JW, Park BK, Jenkins SJ, Simpson KJ, Hume DA, Wigmore SJ, Forbes SJ. Stutchfield BM, et al. Among authors: simpson kj. Gastroenterology. 2015 Dec;149(7):1896-1909.e14. doi: 10.1053/j.gastro.2015.08.053. Epub 2015 Sep 5. Gastroenterology. 2015. PMID: 26344055 Free PMC article.
Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.
Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC. Greenhalgh SN, et al. Among authors: simpson eem, simpson kj. Am J Pathol. 2019 Feb;189(2):258-271. doi: 10.1016/j.ajpath.2018.10.007. Epub 2018 Nov 16. Am J Pathol. 2019. PMID: 30448409 Free PMC article.
288 results