Simpson KJ - Search Results

1

A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens.

Cluse LA, Nikolic I, Knight D, Madhamshettiwar PB, Luu J, Cowley KJ, Semple T, Arnau GM, Shortt J, Johnstone RW, Simpson KJ. Cluse LA, et al. Among authors: simpson kj. Methods Mol Biol. 2018;1725:201-227. doi: 10.1007/978-1-4939-7568-6_17. Methods Mol Biol. 2018. PMID: 29322420

2

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.

Brasacchio D, Noori T, House C, Brennan AJ, Simpson KJ, Susanto O, Bird PI, Johnstone RW, Trapani JA. Brasacchio D, et al. Among authors: simpson kj. Cell Death Differ. 2014 May;21(5):748-60. doi: 10.1038/cdd.2013.203. Epub 2014 Jan 24. Cell Death Differ. 2014. PMID: 24464226 Free PMC article.

3

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma.

Gupte A, Baker EK, Wan SS, Stewart E, Loh A, Shelat AA, Gould CM, Chalk AM, Taylor S, Lackovic K, Karlström Å, Mutsaers AJ, Desai J, Madhamshettiwar PB, Zannettino AC, Burns C, Huang DC, Dyer MA, Simpson KJ, Walkley CR. Gupte A, et al. Among authors: simpson kj. Clin Cancer Res. 2015 Jul 15;21(14):3216-29. doi: 10.1158/1078-0432.CCR-14-3026. Epub 2015 Apr 10. Clin Cancer Res. 2015. PMID: 25862761 Free PMC article.

4

Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat.

Falkenberg KJ, Gould CM, Johnstone RW, Simpson KJ. Falkenberg KJ, et al. Among authors: simpson kj. Sci Data. 2014 Jul 8;1:140017. doi: 10.1038/sdata.2014.17. eCollection 2014. Sci Data. 2014. PMID: 25977774 Free PMC article.

5

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity.

Falkenberg KJ, Newbold A, Gould CM, Luu J, Trapani JA, Matthews GM, Simpson KJ, Johnstone RW. Falkenberg KJ, et al. Among authors: simpson kj. Cell Death Differ. 2016 Jul;23(7):1209-18. doi: 10.1038/cdd.2015.175. Epub 2016 Feb 12. Cell Death Differ. 2016. PMID: 26868908 Free PMC article.

6

An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

Dutta B, Azhir A, Merino LH, Guo Y, Revanur S, Madhamshettiwar PB, Germain RN, Smith JA, Simpson KJ, Martin SE, Buehler E, Fraser ID. Dutta B, et al. Among authors: simpson kj. Nat Commun. 2016 Feb 23;7:10578. doi: 10.1038/ncomms10578. Nat Commun. 2016. PMID: 26902267 Free PMC article.

7

Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour.

Kumarasingha R, Karpe AV, Preston S, Yeo TC, Lim DSL, Tu CL, Luu J, Simpson KJ, Shaw JM, Gasser RB, Beale DJ, Morrison PD, Palombo EA, Boag PR. Kumarasingha R, et al. Among authors: simpson kj. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):171-178. doi: 10.1016/j.ijpddr.2016.08.002. Epub 2016 Aug 26. Int J Parasitol Drugs Drug Resist. 2016. PMID: 27639945 Free PMC article.

8

Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion.

Foo CH, Rootes CL, Cowley K, Marsh GA, Gould CM, Deffrasnes C, Cowled CJ, Klein R, Riddell SJ, Middleton D, Simpson KJ, Wang LF, Bean AG, Stewart CR. Foo CH, et al. Among authors: simpson kj. PLoS Pathog. 2016 Oct 26;12(10):e1005974. doi: 10.1371/journal.ppat.1005974. eCollection 2016 Oct. PLoS Pathog. 2016. PMID: 27783670 Free PMC article.

9

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.

Brasacchio D, Alsop AE, Noori T, Lufti M, Iyer S, Simpson KJ, Bird PI, Kluck RM, Johnstone RW, Trapani JA. Brasacchio D, et al. Among authors: simpson kj. Cell Death Differ. 2017 Jun;24(6):961-970. doi: 10.1038/cdd.2016.119. Epub 2017 Jan 6. Cell Death Differ. 2017. PMID: 28060382 Free PMC article.

10

Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus.

Jiao Y, Preston S, Koehler AV, Stroehlein AJ, Chang BCH, Simpson KJ, Cowley KJ, Palmer MJ, Laleu B, Wells TNC, Jabbar A, Gasser RB. Jiao Y, et al. Among authors: simpson kj. Parasit Vectors. 2017 Jul 5;10(1):323. doi: 10.1186/s13071-017-2246-x. Parasit Vectors. 2017. PMID: 28679424 Free PMC article.

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