Simpson D - Search Results

1

Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities.

Krais JJ, Glass DJ, Chudoba I, Wang Y, Feng W, Simpson D, Patel P, Liu Z, Neumann-Domer R, Betsch RG, Bernhardy AJ, Bradbury AM, Conger J, Yueh WT, Nacson J, Pomerantz RT, Gupta GP, Testa JR, Johnson N. Krais JJ, et al. Among authors: simpson d. Nat Commun. 2023 Nov 24;14(1):7714. doi: 10.1038/s41467-023-43446-1. Nat Commun. 2023. PMID: 38001070 Free PMC article.

2

Genetic determinants of cellular addiction to DNA polymerase theta.

Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP. Feng W, et al. Among authors: simpson da. Nat Commun. 2019 Sep 19;10(1):4286. doi: 10.1038/s41467-019-12234-1. Nat Commun. 2019. PMID: 31537809 Free PMC article.

3

A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability.

Fagan-Solis KD, Simpson DA, Kumar RJ, Martelotto LG, Mose LE, Rashid NU, Ho AY, Powell SN, Wen YH, Parker JS, Reis-Filho JS, Petrini JHJ, Gupta GP. Fagan-Solis KD, et al. Among authors: simpson da. Cell Rep. 2020 Feb 4;30(5):1385-1399.e7. doi: 10.1016/j.celrep.2020.01.020. Cell Rep. 2020. PMID: 32023457 Free PMC article.

4

Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency.

Kumar RJ, Chao HX, Simpson DA, Feng W, Cho MG, Roberts VR, Sullivan AR, Shah SJ, Wozny AS, Fagan-Solis K, Kumar S, Luthman A, Ramsden DA, Purvis JE, Gupta GP. Kumar RJ, et al. NAR Cancer. 2020 Dec;2(4):zcaa038. doi: 10.1093/narcan/zcaa038. Epub 2020 Dec 21. NAR Cancer. 2020. PMID: 33385162 Free PMC article.

5

Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks.

Feng W, Simpson DA, Cho JE, Carvajal-Garcia J, Smith CM, Headley KM, Hathaway N, Ramsden DA, Gupta GP. Feng W, et al. Nucleic Acids Res. 2021 May 21;49(9):5095-5105. doi: 10.1093/nar/gkab299. Nucleic Acids Res. 2021. PMID: 33963863 Free PMC article.

6

Targeting Non-homologous and Alternative End Joining Repair to Enhance Cancer Radiosensitivity.

Feng W, Smith CM, Simpson DA, Gupta GP. Feng W, et al. Semin Radiat Oncol. 2022 Jan;32(1):29-41. doi: 10.1016/j.semradonc.2021.09.007. Semin Radiat Oncol. 2022. PMID: 34861993 Review.

7

MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.

Cho MG, Kumar RJ, Lin CC, Boyer JA, Shahir JA, Fagan-Solis K, Simpson DA, Fan C, Foster CE, Goddard AM, Lerner LM, Ellington SW, Wang Q, Wang Y, Ho AY, Liu P, Perou CM, Zhang Q, McGinty RK, Purvis JE, Gupta GP. Cho MG, et al. Nature. 2024 Jan;625(7995):585-592. doi: 10.1038/s41586-023-06889-6. Epub 2024 Jan 10. Nature. 2024. PMID: 38200309 Free PMC article.

8

Radiation clastogenesis and cell cycle checkpoint function as functional markers of breast cancer risk.

Kaufmann WK, Filatov L, Oglesbee SE, Simpson DA, Lotano MA, McKeen HD, Sawyer LR, Moore DT, Millikan RC, Cordeiro-Stone M, Carey LA. Kaufmann WK, et al. Among authors: simpson da. Carcinogenesis. 2006 Dec;27(12):2519-27. doi: 10.1093/carcin/bgl103. Epub 2006 Jun 15. Carcinogenesis. 2006. PMID: 16777992

9

Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells.

Bower JJ, Vance LD, Psioda M, Smith-Roe SL, Simpson DA, Ibrahim JG, Hoadley KA, Perou CM, Kaufmann WK. Bower JJ, et al. Among authors: simpson da. NPJ Breast Cancer. 2017 Mar 31;3:9. doi: 10.1038/s41523-017-0009-7. eCollection 2017. NPJ Breast Cancer. 2017. PMID: 28649649 Free PMC article.

10

Ataxia telangiectasia-mutated dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts.

Zhou T, Chou J, Zhou Y, Simpson DA, Cao F, Bushel PR, Paules RS, Kaufmann WK. Zhou T, et al. Mol Cancer Res. 2007 Aug;5(8):813-22. doi: 10.1158/1541-7786.MCR-07-0104. Mol Cancer Res. 2007. PMID: 17699107 Free PMC article.

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