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'Rinse and Replace': Boosting T Cell Turnover To Reduce HIV-1 Reservoirs.
Grossman Z, Singh NJ, Simonetti FR, Lederman MM, Douek DC, Deeks SG; Contributing authors. Grossman Z, et al. Among authors: simonetti fr. Trends Immunol. 2020 Jun;41(6):466-480. doi: 10.1016/j.it.2020.04.003. Epub 2020 May 12. Trends Immunol. 2020. PMID: 32414695 Review.
Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo.
Simonetti FR, Sobolewski MD, Fyne E, Shao W, Spindler J, Hattori J, Anderson EM, Watters SA, Hill S, Wu X, Wells D, Su L, Luke BT, Halvas EK, Besson G, Penrose KJ, Yang Z, Kwan RW, Van Waes C, Uldrick T, Citrin DE, Kovacs J, Polis MA, Rehm CA, Gorelick R, Piatak M, Keele BF, Kearney MF, Coffin JM, Hughes SH, Mellors JW, Maldarelli F. Simonetti FR, et al. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1883-8. doi: 10.1073/pnas.1522675113. Epub 2016 Feb 8. Proc Natl Acad Sci U S A. 2016. PMID: 26858442 Free PMC article.
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses.
Bruner KM, Wang Z, Simonetti FR, Bender AM, Kwon KJ, Sengupta S, Fray EJ, Beg SA, Antar AAR, Jenike KM, Bertagnolli LN, Capoferri AA, Kufera JT, Timmons A, Nobles C, Gregg J, Wada N, Ho YC, Zhang H, Margolick JB, Blankson JN, Deeks SG, Bushman FD, Siliciano JD, Laird GM, Siliciano RF. Bruner KM, et al. Among authors: simonetti fr. Nature. 2019 Feb;566(7742):120-125. doi: 10.1038/s41586-019-0898-8. Epub 2019 Jan 30. Nature. 2019. PMID: 30700913 Free PMC article.
Clones of infected cells arise early in HIV-infected individuals.
Coffin JM, Wells DW, Zerbato JM, Kuruc JD, Guo S, Luke BT, Eron JJ, Bale M, Spindler J, Simonetti FR, Hill S, Kearney MF, Maldarelli F, Wu X, Mellors JW, Hughes SH. Coffin JM, et al. Among authors: simonetti fr. JCI Insight. 2019 Jun 20;4(12):e128432. doi: 10.1172/jci.insight.128432. eCollection 2019 Jun 20. JCI Insight. 2019. PMID: 31217357 Free PMC article.
No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication.
Bozzi G, Simonetti FR, Watters SA, Anderson EM, Gouzoulis M, Kearney MF, Rote P, Lange C, Shao W, Gorelick R, Fullmer B, Kumar S, Wank S, Hewitt S, Kleiner DE, Hattori J, Bale MJ, Hill S, Bell J, Rehm C, Grossman Z, Yarchoan R, Uldrick T, Maldarelli F. Bozzi G, et al. Among authors: simonetti fr. Sci Adv. 2019 Sep 25;5(9):eaav2045. doi: 10.1126/sciadv.aav2045. eCollection 2019 Sep. Sci Adv. 2019. PMID: 31579817 Free PMC article.
HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus.
Musick A, Spindler J, Boritz E, Pérez L, Crespo-Vélez D, Patro SC, Sobolewski MD, Bale MJ, Reid C, Keele BF, Capoferri A, Shao W, Wiegand A, Simonetti FR, Mellors JW, Hughes SH, Coffin JM, Maldarelli F, Kearney MF. Musick A, et al. Among authors: simonetti fr. Front Microbiol. 2019 Oct 1;10:2204. doi: 10.3389/fmicb.2019.02204. eCollection 2019. Front Microbiol. 2019. PMID: 31632364 Free PMC article.
Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections.
Anderson EM, Simonetti FR, Gorelick RJ, Hill S, Gouzoulis MA, Bell J, Rehm C, Pérez L, Boritz E, Wu X, Wells D, Hughes SH, Rao V, Coffin JM, Kearney MF, Maldarelli F. Anderson EM, et al. Among authors: simonetti fr. Viruses. 2020 Jan 25;12(2):136. doi: 10.3390/v12020136. Viruses. 2020. PMID: 31991737 Free PMC article.
Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA.
Simonetti FR, White JA, Tumiotto C, Ritter KD, Cai M, Gandhi RT, Deeks SG, Howell BJ, Montaner LJ, Blankson JN, Martin A, Laird GM, Siliciano RF, Mellors JW, Siliciano JD. Simonetti FR, et al. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18692-18700. doi: 10.1073/pnas.2006816117. Epub 2020 Jul 20. Proc Natl Acad Sci U S A. 2020. PMID: 32690683 Free PMC article.
45 results