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Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology.
Nho K, Nudelman K, Allen M, Hodges A, Kim S, Risacher SL, Apostolova LG, Lin K, Lunnon K, Wang X, Burgess JD, Ertekin-Taner N, Petersen RC, Wang L, Qi Z, He A, Neuhaus I, Patel V, Foroud T, Faber KM, Lovestone S, Simmons A, Weiner MW, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative. Nho K, et al. Among authors: simmons a. Alzheimers Dement. 2020 Sep;16(9):1213-1223. doi: 10.1002/alz.12092. Epub 2020 Aug 5. Alzheimers Dement. 2020. PMID: 32755048 Free PMC article.
Dysregulated Fc gamma receptor-mediated phagocytosis pathway in Alzheimer's disease: network-based gene expression analysis.
Park YH, Hodges A, Risacher SL, Lin K, Jang JW, Ahn S, Kim S, Lovestone S, Simmons A, Weiner MW, Saykin AJ, Nho K; AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative. Park YH, et al. Among authors: simmons a. Neurobiol Aging. 2020 Apr;88:24-32. doi: 10.1016/j.neurobiolaging.2019.12.001. Epub 2019 Dec 10. Neurobiol Aging. 2020. PMID: 31901293 Free PMC article.
Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood.
Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Coppola G, Geschwind D, Simmons A, Lovestone S, Dobson R, Hodges A; AddNeuroMed Consortium. Lunnon K, et al. Among authors: simmons a. J Alzheimers Dis. 2012;30(3):685-710. doi: 10.3233/JAD-2012-111592. J Alzheimers Dis. 2012. PMID: 22466004
Protective variant for hippocampal atrophy identified by whole exome sequencing.
Nho K, Kim S, Risacher SL, Shen L, Corneveaux JJ, Swaminathan S, Lin H, Ramanan VK, Liu Y, Foroud TM, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR Jr, Weiner MW, Baldwin CT, Lunetta KL, Farrer LA; MIRAGE (Multi-Institutional Research on Alzheimer Genetic Epidemiology) Study; Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H; AddNeuroMed Consortium; McDonald BC, Farlow MR, Ghetti B; Indiana Memory and Aging Study; Huentelman MJ, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative. Nho K, et al. Among authors: simmons a. Ann Neurol. 2015 Mar;77(3):547-52. doi: 10.1002/ana.24349. Epub 2015 Feb 14. Ann Neurol. 2015. PMID: 25559091 Free PMC article.
Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease.
Horgusluoglu-Moloch E, Nho K, Risacher SL, Kim S, Foroud T, Shaw LM, Trojanowski JQ, Aisen PS, Petersen RC, Jack CR Jr, Lovestone S, Simmons A, Weiner MW, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative (ADNI). Horgusluoglu-Moloch E, et al. Among authors: simmons a. Neurobiol Aging. 2017 Dec;60:92-103. doi: 10.1016/j.neurobiolaging.2017.08.010. Epub 2017 Aug 18. Neurobiol Aging. 2017. PMID: 28941407 Free PMC article.
Association of blood-based transcriptional risk scores with biomarkers for Alzheimer disease.
Park YH, Hodges A, Simmons A, Lovestone S, Weiner MW, Kim S, Saykin AJ, Nho K; AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative. Park YH, et al. Among authors: simmons a. Neurol Genet. 2020 Sep 30;6(6):e517. doi: 10.1212/NXG.0000000000000517. eCollection 2020 Dec. Neurol Genet. 2020. PMID: 33134515 Free PMC article.
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund LO, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Spenger C, Lathrop M, Shen L, Kim S, Saykin AJ, Weiner MW, Lovestone S; Alzheimer’s Disease Neuroimaging Initiative; AddNeuroMed Consortium. Furney SJ, et al. Among authors: simmons a. Mol Psychiatry. 2011 Nov;16(11):1130-8. doi: 10.1038/mp.2010.123. Epub 2010 Nov 30. Mol Psychiatry. 2011. PMID: 21116278 Free PMC article.
Novel genetic loci underlying human intracranial volume identified through genome-wide association.
Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser A, Bernard M, Bis JC, Blanken LM, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chauhan G, Chen Q, Ching CR, Cuellar-Partida G, Braber AD, Doan NT, Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL, Gottesman RF, Greven CU, Grimm O, Griswold ME, Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liao J, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand A, Matarin M, Mather KA, Mattheisen M, Mazoyer B, McKay DR, McWhirter R, Milaneschi Y, Mirza-Schreiber N, Muetzel RL, Maniega SM, Nho K, Nugent AC, Loohuis LM, Oosterlaan J, Papmeyer M, Pappa I, Pirpamer L, Pudas S, Pütz B, Rajan KB, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Rose EJ, Royle NA, Rundek T, Sämann PG, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumska… See abstract for full author list ➔ Adams HH, et al. Among authors: simmons a. Nat Neurosci. 2016 Dec;19(12):1569-1582. doi: 10.1038/nn.4398. Epub 2016 Oct 3. Nat Neurosci. 2016. PMID: 27694991 Free PMC article.
A blood gene expression marker of early Alzheimer's disease.
Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Geschwind D, Lovestone S, Dobson R, Hodges A; dNeuroMed Consortium. Lunnon K, et al. Among authors: simmons a. J Alzheimers Dis. 2013;33(3):737-53. doi: 10.3233/JAD-2012-121363. J Alzheimers Dis. 2013. PMID: 23042217
Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology.
Sattlecker M, Kiddle SJ, Newhouse S, Proitsi P, Nelson S, Williams S, Johnston C, Killick R, Simmons A, Westman E, Hodges A, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S; AddNeuroMed Consortium; Dobson RJ. Sattlecker M, et al. Among authors: simmons a. Alzheimers Dement. 2014 Nov;10(6):724-34. doi: 10.1016/j.jalz.2013.09.016. Epub 2014 Apr 25. Alzheimers Dement. 2014. PMID: 24768341 Free article.
1,364 results