Simmonds RE - Search Results

1

Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F.

O'Keefe S, Bhadra P, Duah KB, Zong G, Tenay L, Andrews L, Schneider H, Anderson A, Hu Z, Aljewari HS, Hall BS, Simmonds RE, Helms V, High S, Shi WQ. O'Keefe S, et al. Among authors: simmonds re. Molecules. 2022 Jul 10;27(14):4419. doi: 10.3390/molecules27144419. Molecules. 2022. PMID: 35889292 Free PMC article.

2

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.

Zong G, Hu Z, O'Keefe S, Tranter D, Iannotti MJ, Baron L, Hall B, Corfield K, Paatero AO, Henderson MJ, Roboti P, Zhou J, Sun X, Govindarajan M, Rohde JM, Blanchard N, Simmonds R, Inglese J, Du Y, Demangel C, High S, Paavilainen VO, Shi WQ. Zong G, et al. J Am Chem Soc. 2019 May 29;141(21):8450-8461. doi: 10.1021/jacs.8b13506. Epub 2019 May 15. J Am Chem Soc. 2019. PMID: 31059257 Free PMC article.

3

The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer.

Hall BS, Hsieh LT, Sacre S, Simmonds RE. Hall BS, et al. Among authors: simmonds re. Front Immunol. 2022 Jan 26;12:788146. doi: 10.3389/fimmu.2021.788146. eCollection 2021. Front Immunol. 2022. PMID: 35154073 Free PMC article.

4

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone.

McKenna M, Simmonds RE, High S. McKenna M, et al. Among authors: simmonds re. J Cell Sci. 2016 Apr 1;129(7):1404-15. doi: 10.1242/jcs.182352. Epub 2016 Feb 11. J Cell Sci. 2016. PMID: 26869228 Free PMC article.

5

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis.

McKenna M, Simmonds RE, High S. McKenna M, et al. Among authors: simmonds re. J Cell Sci. 2017 Apr 1;130(7):1307-1320. doi: 10.1242/jcs.198655. Epub 2017 Feb 20. J Cell Sci. 2017. PMID: 28219954 Free PMC article.

6

Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state.

Bhadra P, Dos Santos S, Gamayun I, Pick T, Neumann C, Ogbechi J, Hall BS, Zimmermann R, Helms V, Simmonds RE, Cavalié A. Bhadra P, et al. Among authors: simmonds re. Biochem J. 2021 Nov 26;478(22):4005-4024. doi: 10.1042/BCJ20210345. Biochem J. 2021. PMID: 34726690 Free PMC article.

7

Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer.

Hall B, Simmonds R. Hall B, et al. Biochem Soc Trans. 2014 Feb;42(1):177-83. doi: 10.1042/BST20130133. Biochem Soc Trans. 2014. PMID: 24450648 Free article. Review.

8

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.

Ogbechi J, Hall BS, Sbarrato T, Taunton J, Willis AE, Wek RC, Simmonds RE. Ogbechi J, et al. Among authors: simmonds re. Cell Death Dis. 2018 Mar 14;9(3):397. doi: 10.1038/s41419-018-0427-y. Cell Death Dis. 2018. PMID: 29540678 Free PMC article.

9

Structure of the Inhibited State of the Sec Translocon.

Gérard SF, Hall BS, Zaki AM, Corfield KA, Mayerhofer PU, Costa C, Whelligan DK, Biggin PC, Simmonds RE, Higgins MK. Gérard SF, et al. Among authors: simmonds re. Mol Cell. 2020 Aug 6;79(3):406-415.e7. doi: 10.1016/j.molcel.2020.06.013. Epub 2020 Jul 9. Mol Cell. 2020. PMID: 32692975 Free PMC article.

10

The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.

Hall BS, Hill K, McKenna M, Ogbechi J, High S, Willis AE, Simmonds RE. Hall BS, et al. Among authors: simmonds re. PLoS Pathog. 2014 Apr 3;10(4):e1004061. doi: 10.1371/journal.ppat.1004061. eCollection 2014 Apr. PLoS Pathog. 2014. PMID: 24699819 Free PMC article.

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