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Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells.
Doshi MB, Lee N, Tseyang T, Ponomarova O, Goel HL, Spears M, Li R, Zhu LJ, Ashwood C, Simin K, Jang C, Mercurio AM, Walhout AJM, Spinelli JB, Kim D. Doshi MB, et al. Among authors: simin k. Nature. 2023 Nov;623(7987):625-632. doi: 10.1038/s41586-023-06676-3. Epub 2023 Oct 25. Nature. 2023. PMID: 37880368 Free PMC article.
Selenium detoxification is required for cancer-cell survival.
Carlisle AE, Lee N, Matthew-Onabanjo AN, Spears ME, Park SJ, Youkana D, Doshi MB, Peppers A, Li R, Joseph AB, Smith M, Simin K, Zhu LJ, Greer PL, Shaw LM, Kim D. Carlisle AE, et al. Among authors: simin k. Nat Metab. 2020 Jul;2(7):603-611. doi: 10.1038/s42255-020-0224-7. Epub 2020 Jul 6. Nat Metab. 2020. PMID: 32694795 Free PMC article.
De novo sphingolipid biosynthesis necessitates detoxification in cancer cells.
Spears ME, Lee N, Hwang S, Park SJ, Carlisle AE, Li R, Doshi MB, Armando AM, Gao J, Simin K, Zhu LJ, Greer PL, Quehenberger O, Torres EM, Kim D. Spears ME, et al. Among authors: simin k. Cell Rep. 2022 Sep 27;40(13):111415. doi: 10.1016/j.celrep.2022.111415. Cell Rep. 2022. PMID: 36170811 Free PMC article.
EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance.
Chibaya L, Murphy KC, DeMarco KD, Gopalan S, Liu H, Parikh CN, Lopez-Diaz Y, Faulkner M, Li J, Morris JP 4th, Ho YJ, Chana SK, Simon J, Luan W, Kulick A, de Stanchina E, Simin K, Zhu LJ, Fazzio TG, Lowe SW, Ruscetti M. Chibaya L, et al. Among authors: simin k. Nat Cancer. 2023 Jun;4(6):872-892. doi: 10.1038/s43018-023-00553-8. Epub 2023 May 4. Nat Cancer. 2023. PMID: 37142692 Free PMC article.
Gene expression signature of atypical breast hyperplasia and regulation by SFRP1.
Gregory KJ, Roberts AL, Conlon EM, Mayfield JA, Hagen MJ, Crisi GM, Bentley BA, Kane JJ, Makari-Judson G, Mason HS, Yu J, Zhu LJ, Simin K, Johnson JPS, Khan A, Schneider BR, Schneider SS, Jerry DJ. Gregory KJ, et al. Among authors: simin k. Breast Cancer Res. 2019 Jun 27;21(1):76. doi: 10.1186/s13058-019-1157-5. Breast Cancer Res. 2019. PMID: 31248446 Free PMC article.
41 results