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TNFα induces endothelial dysfunction in rheumatoid arthritis via LOX-1 and arginase 2: reversal by monoclonal TNFα antibodies.
Akhmedov A, Crucet M, Simic B, Kraler S, Bonetti NR, Ospelt C, Distler O, Ciurea A, Liberale L, Jauhiainen M, Metso J, Miranda M, Cydecian R, Schwarz L, Fehr V, Zilinyi R, Amrollahi-Sharifabadi M, Ntari L, Karagianni N, Ruschitzka F, Laaksonen R, Vanhoutte PM, Kollias G, Camici GG, Lüscher TF. Akhmedov A, et al. Among authors: simic b. Cardiovasc Res. 2022 Jan 7;118(1):254-266. doi: 10.1093/cvr/cvab005. Cardiovasc Res. 2022. PMID: 33483748
The NO-donor MPC-1011 stimulates angiogenesis and arteriogenesis and improves hindlimb ischemia via a cGMP-dependent pathway involving VEGF and SDF-1α.
Gomes de Almeida Schirmer B, Crucet M, Stivala S, Vucicevic G, da Silva Barcelos L, Vanhoutte PM, Pellegrini G, Camici GG, Seebeck P, Pfundstein S, Stein S, Paneni F, Lüscher TF, Simic B. Gomes de Almeida Schirmer B, et al. Among authors: simic b. Atherosclerosis. 2020 Jul;304:30-38. doi: 10.1016/j.atherosclerosis.2020.05.012. Epub 2020 May 30. Atherosclerosis. 2020. PMID: 32574829 Free article.
Torcetrapib impairs endothelial function in hypertension.
Simic B, Hermann M, Shaw SG, Bigler L, Stalder U, Dörries C, Besler C, Lüscher TF, Ruschitzka F. Simic B, et al. Eur Heart J. 2012 Jul;33(13):1615-24. doi: 10.1093/eurheartj/ehr348. Epub 2011 Sep 14. Eur Heart J. 2012. PMID: 21920972 Free article.
Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase.
Simic B, Mocharla P, Crucet M, Osto E, Kratzer A, Stivala S, Kühnast S, Speer T, Doycheva P, Princen HM, van der Hoorn JW, Jukema JW, Giral H, Tailleux A, Landmesser U, Staels B, Lüscher TF. Simic B, et al. Atherosclerosis. 2017 Feb;257:186-194. doi: 10.1016/j.atherosclerosis.2017.01.011. Epub 2017 Jan 16. Atherosclerosis. 2017. PMID: 28152406
Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin.
Kühnast S, van der Tuin SJ, van der Hoorn JW, van Klinken JB, Simic B, Pieterman E, Havekes LM, Landmesser U, Lüscher TF, Willems van Dijk K, Rensen PC, Jukema JW, Princen HM. Kühnast S, et al. Among authors: simic b. Eur Heart J. 2015 Jan 1;36(1):39-48. doi: 10.1093/eurheartj/ehu319. Epub 2014 Aug 20. Eur Heart J. 2015. PMID: 25142968 Free PMC article.
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