Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
Bernstock JD, Ye D, Smith JA, Lee YJ, Gessler FA, Yasgar A, Kouznetsova J, Jadhav A, Wang Z, Pluchino S, Zheng W, Simeonov A, Hallenbeck JM, Yang W.
Bernstock JD, et al. Among authors: simeonov a.
FASEB J. 2018 Mar;32(3):1677-1691. doi: 10.1096/fj.201700711R. Epub 2018 Jan 3.
FASEB J. 2018.
PMID: 29146736
Free PMC article.
The development of novel neuroprotective treatments for acute stroke has been fraught with failures, which supports the view of ischemic brain damage as a highly complex multifactorial process. Post-translational modifications such as small ubiquitin-like modifier (SUMO)yl …
The development of novel neuroprotective treatments for acute stroke has been fraught with failures, which supports the view of ischemic bra …