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Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway.
Bizzozero L, Cazzato D, Cervia D, Assi E, Simbari F, Pagni F, De Palma C, Monno A, Verdelli C, Querini PR, Russo V, Clementi E, Perrotta C. Bizzozero L, et al. Among authors: simbari f. Cell Death Differ. 2014 Apr;21(4):507-20. doi: 10.1038/cdd.2013.173. Epub 2013 Dec 6. Cell Death Differ. 2014. PMID: 24317198 Free PMC article.
Erratum: Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.
Buck AH, Coakley G, Simbari F, McSorley HJ, Quintana JF, Le Bihan T, Kumar S, Abreu-Goodger C, Lear M, Harcus Y, Ceroni A, Babayan SA, Blaxter M, Ivens A, Maizels RM. Buck AH, et al. Among authors: simbari f. Nat Commun. 2015 Oct 22;6:8772. doi: 10.1038/ncomms9772. Nat Commun. 2015. PMID: 26490107 Free PMC article. No abstract available.
Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function.
Perrotta C, Bizzozero L, Cazzato D, Morlacchi S, Assi E, Simbari F, Zhang Y, Gulbins E, Bassi MT, Rosa P, Clementi E. Perrotta C, et al. Among authors: simbari f. J Biol Chem. 2010 Dec 17;285(51):40240-51. doi: 10.1074/jbc.M110.139287. Epub 2010 Oct 18. J Biol Chem. 2010. PMID: 20956541 Free PMC article.
Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.
Jenkins RW, Clarke CJ, Canals D, Snider AJ, Gault CR, Heffernan-Stroud L, Wu BX, Simbari F, Roddy P, Kitatani K, Obeid LM, Hannun YA. Jenkins RW, et al. Among authors: simbari f. J Biol Chem. 2011 Apr 15;286(15):13292-303. doi: 10.1074/jbc.M110.163378. Epub 2011 Feb 18. J Biol Chem. 2011. PMID: 21335555 Free PMC article.
Previously, our laboratory identified Ser(508) as a crucial residue for the constitutive and regulated secretion of S-SMase in response to inflammatory cytokines, and demonstrated a role for S-SMase in formation of select cellular Cer species (Jenkins, R. W., Canals, D., Idkowiak …
Previously, our laboratory identified Ser(508) as a crucial residue for the constitutive and regulated secretion of S-SMase in response to i …
14 results