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Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Bonsor DA, Alexander P, Snead K, Hartig N, Drew M, Messing S, Finci LI, Nissley DV, McCormick F, Esposito D, Rodriguez-Viciana P, Stephen AG, Simanshu DK. Bonsor DA, et al. Among authors: simanshu dk. Nat Struct Mol Biol. 2022 Oct;29(10):966-977. doi: 10.1038/s41594-022-00841-4. Epub 2022 Sep 29. Nat Struct Mol Biol. 2022. PMID: 36175670 Free PMC article.
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.
Dharmaiah S, Bindu L, Tran TH, Gillette WK, Frank PH, Ghirlando R, Nissley DV, Esposito D, McCormick F, Stephen AG, Simanshu DK. Dharmaiah S, et al. Among authors: simanshu dk. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6766-E6775. doi: 10.1073/pnas.1615316113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791178 Free PMC article.
RAS Proteins and Their Regulators in Human Disease.
Simanshu DK, Nissley DV, McCormick F. Simanshu DK, et al. Cell. 2017 Jun 29;170(1):17-33. doi: 10.1016/j.cell.2017.06.009. Cell. 2017. PMID: 28666118 Free PMC article. Review.
RIT1 oncoproteins escape LZTR1-mediated proteolysis.
Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F. Castel P, et al. Among authors: simanshu dk. Science. 2019 Mar 15;363(6432):1226-1230. doi: 10.1126/science.aav1444. Science. 2019. PMID: 30872527 Free PMC article.
KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.
Rabara D, Tran TH, Dharmaiah S, Stephens RM, McCormick F, Simanshu DK, Holderfield M. Rabara D, et al. Among authors: simanshu dk. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22122-22131. doi: 10.1073/pnas.1908353116. Epub 2019 Oct 14. Proc Natl Acad Sci U S A. 2019. PMID: 31611389 Free PMC article.
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, Ng RWS, Gautam P, Bryant KL, Esposito D, Campbell SL, Petricoin EF 3rd, Simanshu DK, Aguirre AJ, Wolpin BM, Wennerberg K, Rudloff U, Cox AD, Der CJ. Hobbs GA, et al. Among authors: simanshu dk. Cancer Discov. 2020 Jan;10(1):104-123. doi: 10.1158/2159-8290.CD-19-1006. Epub 2019 Oct 24. Cancer Discov. 2020. PMID: 31649109 Free PMC article.
Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior.
Goswami D, Chen D, Yang Y, Gudla PR, Columbus J, Worthy K, Rigby M, Wheeler M, Mukhopadhyay S, Powell K, Burgan W, Wall V, Esposito D, Simanshu DK, Lightstone FC, Nissley DV, McCormick F, Turbyville T. Goswami D, et al. Among authors: simanshu dk. Elife. 2020 Jan 20;9:e47654. doi: 10.7554/eLife.47654. Elife. 2020. PMID: 31958057 Free PMC article.
The small molecule BI-2852 induces a nonfunctional dimer of KRAS.
Tran TH, Alexander P, Dharmaiah S, Agamasu C, Nissley DV, McCormick F, Esposito D, Simanshu DK, Stephen AG, Balius TE. Tran TH, et al. Among authors: simanshu dk. Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3363-3364. doi: 10.1073/pnas.1918164117. Epub 2020 Feb 11. Proc Natl Acad Sci U S A. 2020. PMID: 32047043 Free PMC article. No abstract available.
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling.
Nelson AC, Turbyville TJ, Dharmaiah S, Rigby M, Yang R, Wang TY, Columbus J, Stephens R, Taylor T, Sciacca D, Onsongo G, Sarver A, Subramanian S, Nissley DV, Simanshu DK, Lou E. Nelson AC, et al. Among authors: simanshu dk. J Biol Chem. 2020 Jul 10;295(28):9335-9348. doi: 10.1074/jbc.RA119.011080. Epub 2020 May 11. J Biol Chem. 2020. PMID: 32393580 Free PMC article.
61 results