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Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion.
Joas S, Sauermann U, Roshani B, Klippert A, Daskalaki M, Mätz-Rensing K, Stolte-Leeb N, Heigele A, Tharp GK, Gupta PM, Nelson S, Bosinger S, Parodi L, Giavedoni L, Silvestri G, Sauter D, Stahl-Hennig C, Kirchhoff F. Joas S, et al. Among authors: silvestri g. Cell Rep. 2020 Feb 18;30(7):2261-2274.e7. doi: 10.1016/j.celrep.2020.01.069. Cell Rep. 2020. PMID: 32075764 Free PMC article.
Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein.
Staprans SI, Barry AP, Silvestri G, Safrit JT, Kozyr N, Sumpter B, Nguyen H, McClure H, Montefiori D, Cohen JI, Feinberg MB. Staprans SI, et al. Among authors: silvestri g. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13026-31. doi: 10.1073/pnas.0404739101. Epub 2004 Aug 23. Proc Natl Acad Sci U S A. 2004. PMID: 15326293 Free PMC article.
Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.
Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, Hahn BH, Kirchhoff F. Schindler M, et al. Among authors: silvestri g. Cell. 2006 Jun 16;125(6):1055-67. doi: 10.1016/j.cell.2006.04.033. Cell. 2006. PMID: 16777597 Free article.
Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys.
Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, Dunham RM, Paiardini M, Klucking S, Danesh A, Strobert EA, Apetrei C, Pandrea IV, Kelvin D, Douek DC, Staprans SI, Sodora DL, Silvestri G. Gordon SN, et al. Among authors: silvestri g. J Immunol. 2007 Sep 1;179(5):3026-34. doi: 10.4049/jimmunol.179.5.3026. J Immunol. 2007. PMID: 17709517 Free PMC article.
Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host.
Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL. Milush JM, et al. Among authors: silvestri g. J Immunol. 2007 Sep 1;179(5):3047-56. doi: 10.4049/jimmunol.179.5.3047. J Immunol. 2007. PMID: 17709519
Enhancing SIV-specific immunity in vivo by PD-1 blockade.
Velu V, Titanji K, Zhu B, Husain S, Pladevega A, Lai L, Vanderford TH, Chennareddi L, Silvestri G, Freeman GJ, Ahmed R, Amara RR. Velu V, et al. Among authors: silvestri g. Nature. 2009 Mar 12;458(7235):206-10. doi: 10.1038/nature07662. Epub 2008 Dec 10. Nature. 2009. PMID: 19078956 Free PMC article.
Conservation of Nef function across highly diverse lineages of SIVsmm.
Schmökel J, Li H, Bailes E, Schindler M, Silvestri G, Hahn BH, Apetrei C, Kirchhoff F. Schmökel J, et al. Among authors: silvestri g. Retrovirology. 2009 Apr 9;6:36. doi: 10.1186/1742-4690-6-36. Retrovirology. 2009. PMID: 19358735 Free PMC article.
1,047 results