Silverman RB - Search Results

1

Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis.

Elmansy MF, Reidl CT, Rahaman M, Özdinler PH, Silverman RB. Elmansy MF, et al. Among authors: silverman rb. Med Res Rev. 2023 Nov;43(6):2260-2302. doi: 10.1002/med.21974. Epub 2023 May 26. Med Res Rev. 2023. PMID: 37243319 Review.

2

Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.

Chen T, Benmohamed R, Arvanites AC, Ralay Ranaivo H, Morimoto RI, Ferrante RJ, Watterson DM, Kirsch DR, Silverman RB. Chen T, et al. Among authors: silverman rb. Bioorg Med Chem. 2011 Jan 1;19(1):613-22. doi: 10.1016/j.bmc.2010.10.052. Epub 2010 Oct 30. Bioorg Med Chem. 2011. PMID: 21095130 Free PMC article.

3

Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis.

Xia G, Benmohamed R, Kim J, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Xia G, et al. Among authors: silverman rb. J Med Chem. 2011 Apr 14;54(7):2409-21. doi: 10.1021/jm101549k. Epub 2011 Mar 4. J Med Chem. 2011. PMID: 21375347 Free PMC article.

4

ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.

Chen T, Benmohamed R, Kim J, Smith K, Amante D, Morimoto RI, Kirsch DR, Ferrante RJ, Silverman RB. Chen T, et al. Among authors: silverman rb. J Med Chem. 2012 Jan 12;55(1):515-27. doi: 10.1021/jm2014277. Epub 2011 Dec 22. J Med Chem. 2012. PMID: 22191331 Free PMC article.

5

Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis.

Zhang Y, Benmohamed R, Huang H, Chen T, Voisine C, Morimoto RI, Kirsch DR, Silverman RB. Zhang Y, et al. Among authors: silverman rb. J Med Chem. 2013 Mar 28;56(6):2665-75. doi: 10.1021/jm400079a. Epub 2013 Mar 15. J Med Chem. 2013. PMID: 23445362 Free PMC article.

6

Ornithine aminotransferase versus GABA aminotransferase: implications for the design of new anticancer drugs.

Lee H, Juncosa JI, Silverman RB. Lee H, et al. Among authors: silverman rb. Med Res Rev. 2015 Mar;35(2):286-305. doi: 10.1002/med.21328. Epub 2014 Aug 22. Med Res Rev. 2015. PMID: 25145640 Free PMC article. Review.

7

Treatment of amyotrophic lateral sclerosis: lessons learned from many failures.

Ozdinler PH, Silverman RB. Ozdinler PH, et al. Among authors: silverman rb. ACS Med Chem Lett. 2014 Oct 8;5(11):1179-81. doi: 10.1021/ml500404b. eCollection 2014 Nov 13. ACS Med Chem Lett. 2014. PMID: 25408825 Free PMC article.

8

Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis.

Zhang Y, Zhao KT, Fox SG, Kim J, Kirsch DR, Ferrante RJ, Morimoto RI, Silverman RB. Zhang Y, et al. Among authors: silverman rb. J Med Chem. 2015 Aug 13;58(15):5942-9. doi: 10.1021/acs.jmedchem.5b00561. Epub 2015 Jul 31. J Med Chem. 2015. PMID: 26186011 Free PMC article.

9

Inducible nitric oxide synthase: Regulation, structure, and inhibition.

Cinelli MA, Do HT, Miley GP, Silverman RB. Cinelli MA, et al. Among authors: silverman rb. Med Res Rev. 2020 Jan;40(1):158-189. doi: 10.1002/med.21599. Epub 2019 Jun 13. Med Res Rev. 2020. PMID: 31192483 Free PMC article. Review.

10

First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.

Cinelli MA, Reidl CT, Li H, Chreifi G, Poulos TL, Silverman RB. Cinelli MA, et al. Among authors: silverman rb. J Med Chem. 2020 May 14;63(9):4528-4554. doi: 10.1021/acs.jmedchem.9b01573. Epub 2020 Apr 17. J Med Chem. 2020. PMID: 32302123 Free PMC article.

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