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Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment.
Lechner L, Opitz R, Silver MJ, Krabusch PM, Prentice AM, Field MS, Stachelscheid H, Leitão E, Schröder C, Fernandez Vallone V, Horsthemke B, Jöckel KH, Schmidt B, Nöthen MM, Hoffmann P, Herms S, Kleyn PW, Megges M, Blume-Peytavi U, Weiss K, Mai K, Blankenstein O, Obermayer B, Wiegand S, Kühnen P. Lechner L, et al. Among authors: silver mj. Sci Transl Med. 2023 Jul 19;15(705):eadg1659. doi: 10.1126/scitranslmed.adg1659. Epub 2023 Jul 19. Sci Transl Med. 2023. PMID: 37467315
Exposure to aflatoxin B1 in utero is associated with DNA methylation in white blood cells of infants in The Gambia.
Hernandez-Vargas H, Castelino J, Silver MJ, Dominguez-Salas P, Cros MP, Durand G, Le Calvez-Kelm F, Prentice AM, Wild CP, Moore SE, Hennig BJ, Herceg Z, Gong YY, Routledge MN. Hernandez-Vargas H, et al. Among authors: silver mj. Int J Epidemiol. 2015 Aug;44(4):1238-48. doi: 10.1093/ije/dyv027. Epub 2015 Apr 7. Int J Epidemiol. 2015. PMID: 25855716 Free PMC article.
DNA methylation at a nutritionally sensitive region of the PAX8 gene is associated with thyroid volume and function in Gambian children.
Candler T, Kessler NJ, Gunasekara CJ, Ward KA, James P, Laritsky E, Baker MS, Dyer R, Elango R, Jeffries D, Waterland RA, Moore SE, Ludgate M, Prentice AM, Silver MJ. Candler T, et al. Among authors: silver mj. Sci Adv. 2021 Nov 5;7(45):eabj1561. doi: 10.1126/sciadv.abj1561. Epub 2021 Nov 5. Sci Adv. 2021. PMID: 34739318 Free PMC article.
Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.
Dominguez-Salas P, Moore SE, Baker MS, Bergen AW, Cox SE, Dyer RA, Fulford AJ, Guan Y, Laritsky E, Silver MJ, Swan GE, Zeisel SH, Innis SM, Waterland RA, Prentice AM, Hennig BJ. Dominguez-Salas P, et al. Among authors: silver mj. Nat Commun. 2014 Apr 29;5:3746. doi: 10.1038/ncomms4746. Nat Commun. 2014. PMID: 24781383 Free PMC article.
188 results