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Immunomodulatory activity of trifluoromethyl arylamides derived from the SRPK inhibitor SRPIN340 and their potential use as vaccine adjuvant.
Mendes FC, de Paiva JC, da Silva EQG, Santos MR, de Almeida Lima GD, Moreira GA, Silva LVG, de Melo Agripino J, de Souza APM, de Oliveira Mendes TA, Machado-Neves M, Teixeira RR, Silva-Júnior A, Fietto JLR, de Oliveira LL, Bressan GC. Mendes FC, et al. Among authors: silva lvg. Life Sci. 2022 Oct 15;307:120849. doi: 10.1016/j.lfs.2022.120849. Epub 2022 Aug 1. Life Sci. 2022. PMID: 35926588 Free article.
The SRPK inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl) isonicotinamide (SRPIN340) increases the immune response against metastatic melanoma in mice.
Moreira GA, Caetano MMM, do Vale JA, de Paiva JC, Gonçalves VHS, Almeida AA, Silva LVG, Martim FRG, de Andrade Barros MV, Guimarães GR, de Oliveira Santos L, de Souza APM, Machado-Neves M, Teixeira RR, Silva-Júnior A, Fietto JLR, Boroni M, de Oliveira LL, Bressan GC. Moreira GA, et al. Among authors: silva lvg. Biochem Pharmacol. 2022 Sep;203:115161. doi: 10.1016/j.bcp.2022.115161. Epub 2022 Jul 2. Biochem Pharmacol. 2022. PMID: 35787994 Free article.