Silman I - Search Results

1

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice.

Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sánchez-López E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Pérez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, García ML, Camins A, Silman I, Jean L, Inestrosa NC, Colletier JP, Renard PY, Muñoz-Torrero D. Viayna E, et al. Among authors: silman i. J Med Chem. 2021 Jan 14;64(1):812-839. doi: 10.1021/acs.jmedchem.0c01775. Epub 2020 Dec 28. J Med Chem. 2021. PMID: 33356266

2

A membrane-associated dimer of acetylcholinesterase from Xenopus skeletal muscle is solubilized by phosphatidylinositol-specific phospholipase C.

Inestrosa NC, Fuentes ME, Anglister L, Futerman AH, Silman I. Inestrosa NC, et al. Among authors: silman i. Neurosci Lett. 1988 Jul 19;90(1-2):186-90. doi: 10.1016/0304-3940(88)90809-9. Neurosci Lett. 1988. PMID: 3412641

3

A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation.

De Ferrari GV, Canales MA, Shin I, Weiner LM, Silman I, Inestrosa NC. De Ferrari GV, et al. Among authors: silman i. Biochemistry. 2001 Sep 4;40(35):10447-57. doi: 10.1021/bi0101392. Biochemistry. 2001. PMID: 11523986

4

3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.

Dvir H, Wong DM, Harel M, Barril X, Orozco M, Luque FJ, Muñoz-Torrero D, Camps P, Rosenberry TL, Silman I, Sussman JL. Dvir H, et al. Among authors: silman i. Biochemistry. 2002 Mar 5;41(9):2970-81. doi: 10.1021/bi011652i. Biochemistry. 2002. PMID: 11863435

5

Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease.

Greenblatt HM, Dvir H, Silman I, Sussman JL. Greenblatt HM, et al. Among authors: silman i. J Mol Neurosci. 2003;20(3):369-83. doi: 10.1385/JMN:20:3:369. J Mol Neurosci. 2003. PMID: 14501022 Review.

6

Structural insights into substrate traffic and inhibition in acetylcholinesterase.

Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M. Colletier JP, et al. Among authors: silman i. EMBO J. 2006 Jun 21;25(12):2746-56. doi: 10.1038/sj.emboj.7601175. Epub 2006 Jun 8. EMBO J. 2006. PMID: 16763558 Free PMC article.

7

Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.

Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL. Rydberg EH, et al. Among authors: silman i. J Med Chem. 2006 Sep 7;49(18):5491-500. doi: 10.1021/jm060164b. J Med Chem. 2006. PMID: 16942022

8

Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.

Haviv H, Wong DM, Silman I, Sussman JL. Haviv H, et al. Among authors: silman i. Curr Top Med Chem. 2007;7(4):375-87. doi: 10.2174/156802607779941215. Curr Top Med Chem. 2007. PMID: 17305579 Review.

9

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography.

Colletier JP, Royant A, Specht A, Sanson B, Nachon F, Masson P, Zaccai G, Sussman JL, Goeldner M, Silman I, Bourgeois D, Weik M. Colletier JP, et al. Among authors: silman i. Acta Crystallogr D Biol Crystallogr. 2007 Nov;63(Pt 11):1115-28. doi: 10.1107/S0907444907044472. Epub 2007 Oct 17. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 18007027

10

Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics.

Xu Y, Colletier JP, Weik M, Jiang H, Moult J, Silman I, Sussman JL. Xu Y, et al. Among authors: silman i. Biophys J. 2008 Sep;95(5):2500-11. doi: 10.1529/biophysj.108.129601. Epub 2008 May 23. Biophys J. 2008. PMID: 18502801 Free PMC article.

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