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LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation.
Zulato E, Ciccarese F, Agnusdei V, Pinazza M, Nardo G, Iorio E, Curtarello M, Silic-Benussi M, Rossi E, Venturoli C, Panieri E, Santoro MM, Di Paolo V, Quintieri L, Ciminale V, Indraccolo S. Zulato E, et al. Biochem Pharmacol. 2018 Oct;156:479-490. doi: 10.1016/j.bcp.2018.09.019. Epub 2018 Sep 15. Biochem Pharmacol. 2018. PMID: 30222967
mTOR inhibition downregulates glucose-6-phosphate dehydrogenase and induces ROS-dependent death in T-cell acute lymphoblastic leukemia cells.
Silic-Benussi M, Sharova E, Ciccarese F, Cavallari I, Raimondi V, Urso L, Corradin A, Kotler H, Scattolin G, Buldini B, Francescato S, Basso G, Minuzzo SA, Indraccolo S, D'Agostino DM, Ciminale V. Silic-Benussi M, et al. Redox Biol. 2022 May;51:102268. doi: 10.1016/j.redox.2022.102268. Epub 2022 Feb 24. Redox Biol. 2022. PMID: 35248829 Free PMC article.
Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells.
Ciccarese F, Raimondi V, Sharova E, Silic-Benussi M, Ciminale V. Ciccarese F, et al. Among authors: silic benussi m. Antioxidants (Basel). 2020 Mar 4;9(3):211. doi: 10.3390/antiox9030211. Antioxidants (Basel). 2020. PMID: 32143322 Free PMC article.
36 results