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Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities.
Gupton JT, Yeudall S, Telang N, Hoerrner M, Huff E, Crawford E, Lounsbury K, Kimmel M, Curry W, Harrison A, Juekun W, Shimozono A, Ortolani J, Lescalleet K, Patteson J, Moore-Stoll V, Rohena CC, Mooberry SL, Obaidullah AJ, Kellogg GE, Sikorski JA. Gupton JT, et al. Among authors: sikorski ja. Bioorg Med Chem. 2017 Jun 15;25(12):3206-3214. doi: 10.1016/j.bmc.2017.04.012. Epub 2017 Apr 11. Bioorg Med Chem. 2017. PMID: 28433513 Free PMC article.
Application of vinylogous carbamates and vinylogous aminonitriles to the regiospecific synthesis of uniquely functionalized pyrroles and quinolones.
Gupton JT, Crawford E, Mahoney M, Clark E, Curry W, Lane A, Shimozono A, Moore-Stoll V, Elofson K, Juekun W, Newton M, Yeudall S, Jaekle E, Kanters R, Sikorski JA. Gupton JT, et al. Among authors: sikorski ja. Tetrahedron. 2018 Dec 27;74(52):7408-7420. doi: 10.1016/j.tet.2018.10.078. Epub 2018 Nov 5. Tetrahedron. 2018. PMID: 31289413 Free PMC article.
The Application of Vinylogous Iminium Salt Derivatives and Microwave Accelerated Vilsmeier-Haack Reactions to Efficient Relay Syntheses of the Polycitone and Storniamide Natural Products.
Gupton JT, Banner EJ, Sartin MD, Coppock MB, Hempel JE, Kharlamova A, Fisher DC, Giglio BC, Smith KL, Keough MJ, Smith TM, Kanters RP, Dominey RN, Sikorski JA. Gupton JT, et al. Among authors: sikorski ja. Tetrahedron. 2008;64(22):5246-5253. doi: 10.1016/j.tet.2008.03.038. Tetrahedron. 2008. PMID: 18709182 Free PMC article.
Further studies on the application of vinylogous amides and β-halovinylaldehydes to the regiospecific synthesis of unsymmetrical, polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles.
Gupton JT, Shimozono A, Crawford E, Ortolani J, Clark E, Mahoney M, Heese C, Noble J, Mandry CP, Kanters R, Dominey RN, Goldman EW, Sikorski JA, Fisher DC. Gupton JT, et al. Among authors: sikorski ja. Tetrahedron. 2018 May 24;74(21):2650-2663. doi: 10.1016/j.tet.2018.04.017. Epub 2018 Apr 7. Tetrahedron. 2018. PMID: 30344350 Free PMC article.
Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein.
Durley RC, Grapperhaus ML, Hickory BS, Massa MA, Wang JL, Spangler DP, Mischke DA, Parnas BL, Fobian YM, Rath NP, Honda DD, Zeng M, Connolly DT, Heuvelman DM, Witherbee BJ, Melton MA, Glenn KC, Krul ES, Smith ME, Sikorski JA. Durley RC, et al. Among authors: sikorski ja. J Med Chem. 2002 Aug 29;45(18):3891-904. doi: 10.1021/jm020038h. J Med Chem. 2002. PMID: 12190312
Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
Devadas B, Freeman SK, Zupec ME, Lu HF, Nagarajan SR, Kishore NS, Lodge JK, Kuneman DW, McWherter CA, Vinjamoori DV, Getman DP, Gordon JI, Sikorski JA. Devadas B, et al. Among authors: sikorski ja. J Med Chem. 1997 Aug 1;40(16):2609-25. doi: 10.1021/jm970094w. J Med Chem. 1997. PMID: 9258368
Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein.
Reinhard EJ, Wang JL, Durley RC, Fobian YM, Grapperhaus ML, Hickory BS, Massa MA, Norton MB, Promo MA, Tollefson MB, Vernier WF, Connolly DT, Witherbee BJ, Melton MA, Regina KJ, Smith ME, Sikorski JA. Reinhard EJ, et al. Among authors: sikorski ja. J Med Chem. 2003 May 22;46(11):2152-68. doi: 10.1021/jm020528+. J Med Chem. 2003. PMID: 12747787
46 results