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Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo.
Ding X, Sharko AC, McDermott MSJ, Schools GP, Chumanevich A, Ji H, Li J, Zhang L, Mack ZT, Sikirzhytski V, Shtutman M, Ivers L, O'Donovan N, Crown J, Győrffy B, Chen M, Roninson IB, Broude EV. Ding X, et al. Among authors: sikirzhytski v. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2201073119. doi: 10.1073/pnas.2201073119. Epub 2022 Aug 1. Proc Natl Acad Sci U S A. 2022. PMID: 35914167 Free PMC article.
Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation.
Aksenova M, Sybrandt J, Cui B, Sikirzhytski V, Ji H, Odhiambo D, Lucius MD, Turner JR, Broude E, Peña E, Lizarraga S, Zhu J, Safro I, Wyatt MD, Shtutman M. Aksenova M, et al. Among authors: sikirzhytski v. J Neuroimmune Pharmacol. 2020 Jun;15(2):209-223. doi: 10.1007/s11481-019-09885-8. Epub 2019 Dec 4. J Neuroimmune Pharmacol. 2020. PMID: 31802418 Free PMC article.
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Cui BC, Sikirzhytski V, Aksenova M, Lucius MD, Levon GH, Mack ZT, Pollack C, Odhiambo D, Broude E, Lizarraga SB, Wyatt MD, Shtutman M. Cui BC, et al. Among authors: sikirzhytski v. Biochem Pharmacol. 2020 Dec;182:114280. doi: 10.1016/j.bcp.2020.114280. Epub 2020 Oct 10. Biochem Pharmacol. 2020. PMID: 33049245 Free PMC article.
Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer.
Saatci O, Kaymak A, Raza U, Ersan PG, Akbulut O, Banister CE, Sikirzhytski V, Tokat UM, Aykut G, Ansari SA, Dogan HT, Dogan M, Jandaghi P, Isik A, Gundogdu F, Kosemehmetoglu K, Dizdar O, Aksoy S, Akyol A, Uner A, Buckhaults PJ, Riazalhosseini Y, Sahin O. Saatci O, et al. Among authors: sikirzhytski v. Nat Commun. 2020 May 15;11(1):2416. doi: 10.1038/s41467-020-16199-4. Nat Commun. 2020. PMID: 32415208 Free PMC article.
Mediator kinase inhibition reverses castration resistance of advanced prostate cancer.
Li J, Hilimire TA, Yueying L, Wang L, Liang J, Győrffy B, Sikirzhytski V, Ji H, Zhang L, Cheng C, Ding X, Kerr KR, Dowling CE, Chumanevich AA, Mack ZT, Schools GP, Lim CU, Ellis L, Zi X, Porter DC, Broude EV, McInnes C, Wilding G, Lilly MB, Roninson IB, Chen M. Li J, et al. Among authors: sikirzhytski v. J Clin Invest. 2024 Mar 28:e176709. doi: 10.1172/JCI176709. Online ahead of print. J Clin Invest. 2024. PMID: 38546787 Free article.
Raman spectroscopy and machine learning for biomedical applications: Alzheimer's disease diagnosis based on the analysis of cerebrospinal fluid.
Ryzhikova E, Ralbovsky NM, Sikirzhytski V, Kazakov O, Halamkova L, Quinn J, Zimmerman EA, Lednev IK. Ryzhikova E, et al. Among authors: sikirzhytski v. Spectrochim Acta A Mol Biomol Spectrosc. 2021 Mar 5;248:119188. doi: 10.1016/j.saa.2020.119188. Epub 2020 Nov 13. Spectrochim Acta A Mol Biomol Spectrosc. 2021. PMID: 33268033
31 results