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Immune-Response Patterns and Next Generation Sequencing Diagnostics for the Detection of Mycoses in Patients with Septic Shock-Results of a Combined Clinical and Experimental Investigation.
Decker SO, Sigl A, Grumaz C, Stevens P, Vainshtein Y, Zimmermann S, Weigand MA, Hofer S, Sohn K, Brenner T. Decker SO, et al. Among authors: sigl a. Int J Mol Sci. 2017 Aug 18;18(8):1796. doi: 10.3390/ijms18081796. Int J Mol Sci. 2017. PMID: 28820494 Free PMC article.
FimH Antagonists: Phosphate Prodrugs Improve Oral Bioavailability.
Kleeb S, Jiang X, Frei P, Sigl A, Bezençon J, Bamberger K, Schwardt O, Ernst B. Kleeb S, et al. Among authors: sigl a. J Med Chem. 2016 Apr 14;59(7):3163-82. doi: 10.1021/acs.jmedchem.5b01923. Epub 2016 Mar 18. J Med Chem. 2016. PMID: 26959338
FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile.
Kleeb S, Pang L, Mayer K, Eris D, Sigl A, Preston RC, Zihlmann P, Sharpe T, Jakob RP, Abgottspon D, Hutter AS, Scharenberg M, Jiang X, Navarra G, Rabbani S, Smiesko M, Lüdin N, Bezençon J, Schwardt O, Maier T, Ernst B. Kleeb S, et al. Among authors: sigl a. J Med Chem. 2015 Mar 12;58(5):2221-39. doi: 10.1021/jm501524q. Epub 2015 Feb 20. J Med Chem. 2015. PMID: 25666045
16 results