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The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation.
Flegel J, Shaaban S, Jia ZJ, Schulte B, Lian Y, Krzyzanowski A, Metz M, Schneidewind T, Wesseler F, Flegel A, Reich A, Brause A, Xue G, Zhang M, Dötsch L, Stender ID, Hoffmann JE, Scheel R, Janning P, Rastinejad F, Schade D, Strohmann C, Antonchick AP, Sievers S, Moura-Alves P, Ziegler S, Waldmann H. Flegel J, et al. Among authors: sievers s. J Med Chem. 2022 Dec 22;65(24):16268-16289. doi: 10.1021/acs.jmedchem.2c00956. Epub 2022 Dec 2. J Med Chem. 2022. PMID: 36459434 Free PMC article.
Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.
Němec V, Hylsová M, Maier L, Flegel J, Sievers S, Ziegler S, Schröder M, Berger BT, Chaikuad A, Valčíková B, Uldrijan S, Drápela S, Souček K, Waldmann H, Knapp S, Paruch K. Němec V, et al. Among authors: sievers s. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066. doi: 10.1002/anie.201810312. Epub 2018 Dec 20. Angew Chem Int Ed Engl. 2019. PMID: 30569600
Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3.
Ceballos J, Schwalfenberg M, Karageorgis G, Reckzeh ES, Sievers S, Ostermann C, Pahl A, Sellstedt M, Nowacki J, Carnero Corrales MA, Wilke J, Laraia L, Tschapalda K, Metz M, Sehr DA, Brand S, Winklhofer K, Janning P, Ziegler S, Waldmann H. Ceballos J, et al. Among authors: sievers s. Angew Chem Int Ed Engl. 2019 Nov 18;58(47):17016-17025. doi: 10.1002/anie.201909518. Epub 2019 Oct 7. Angew Chem Int Ed Engl. 2019. PMID: 31469221 Free PMC article.
A Scaffold-Diversity Synthesis of Biologically Intriguing Cyclic Sulfonamides.
Zimmermann S, Akbarzadeh M, Otte F, Strohmann C, Sankar MG, Ziegler S, Pahl A, Sievers S, Kumar K. Zimmermann S, et al. Among authors: sievers s. Chemistry. 2019 Dec 5;25(68):15498-15503. doi: 10.1002/chem.201904175. Epub 2019 Nov 7. Chemistry. 2019. PMID: 31518018 Free PMC article.
Image-Based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor.
Laraia L, Garivet G, Foley DJ, Kaiser N, Müller S, Zinken S, Pinkert T, Wilke J, Corkery D, Pahl A, Sievers S, Janning P, Arenz C, Wu Y, Rodriguez R, Waldmann H. Laraia L, et al. Among authors: sievers s. Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5721-5729. doi: 10.1002/anie.201913712. Epub 2020 Jan 24. Angew Chem Int Ed Engl. 2020. PMID: 31769920 Free PMC article.
185 results