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Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction.
Hammer SS, Vieira CP, McFarland D, Sandler M, Levitsky Y, Dorweiler TF, Lydic TA, Asare-Bediako B, Adu-Agyeiwaah Y, Sielski MS, Dupont M, Longhini AL, Li Calzi S, Chakraborty D, Seigel GM, Proshlyakov DA, Grant MB, Busik JV. Hammer SS, et al. Among authors: sielski ms. Diabetologia. 2021 Jul;64(7):1674-1689. doi: 10.1007/s00125-021-05431-5. Epub 2021 Mar 26. Diabetologia. 2021. PMID: 33770194 Free PMC article.
Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes.
Vieira CP, Fortmann SD, Hossain M, Longhini AL, Hammer SS, Asare-Bediako B, Crossman DK, Sielski MS, Adu-Agyeiwaah Y, Dupont M, Floyd JL, Li Calzi S, Lydic T, Welner RS, Blanchard GJ, Busik JV, Grant MB. Vieira CP, et al. Among authors: sielski ms. JCI Insight. 2020 Jul 9;5(13):e137230. doi: 10.1172/jci.insight.137230. JCI Insight. 2020. PMID: 32641586 Free PMC article.
Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic mice.
Gil CH, Chakraborty D, Vieira CP, Prasain N, Li Calzi S, Fortmann SD, Hu P, Banno K, Jamal M, Huang C, Sielski MS, Lin Y, Huang X, Dupont MD, Floyd JL, Prasad R, Longhini ALF, McGill TJ, Chung HM, Murphy MP, Kotton DN, Boulton ME, Yoder MC, Grant MB. Gil CH, et al. Among authors: sielski ms. Sci Adv. 2022 Mar 4;8(9):eabm5559. doi: 10.1126/sciadv.abm5559. Epub 2022 Mar 4. Sci Adv. 2022. PMID: 35245116 Free PMC article.