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Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.
Gilleran JA, Ashraf K, Delvillar M, Eck T, Fondekar R, Miller EB, Hutchinson A, Dong A, Seitova A, De Souza ML, Augeri D, Halabelian L, Siekierka J, Rotella DP, Gordon J, Childers WE, Grier MC, Staker BL, Roberge JY, Bhanot P. Gilleran JA, et al. Among authors: siekierka j. J Med Chem. 2024 Mar 14;67(5):3467-3503. doi: 10.1021/acs.jmedchem.3c01795. Epub 2024 Feb 19. J Med Chem. 2024. PMID: 38372781
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization.
Hawryluk N, Zhiru L, Carlow C, Gokool S, Townson S, Kreiss T, Chojnowski A, Prorok M, Siekierka J, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Canan S, Khetani V, Zeldis J, Specht S, Hübner MP, Scandale I. Hawryluk N, et al. Among authors: siekierka j. Int J Parasitol Drugs Drug Resist. 2022 Aug;19:89-97. doi: 10.1016/j.ijpddr.2022.06.002. Epub 2022 Jun 23. Int J Parasitol Drugs Drug Resist. 2022. PMID: 35834918 Free PMC article.
Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.
Bheemanaboina RRY, de Souza ML, Gonzalez ML, Mahmood SU, Eck T, Kreiss T, Aylor SO, Roth A, Lee P, Pybus BS, Colussi DJ, Childers WE, Gordon J, Siekierka JJ, Bhanot P, Rotella DP. Bheemanaboina RRY, et al. Among authors: siekierka jj. ACS Med Chem Lett. 2021 Nov 15;12(12):1962-1967. doi: 10.1021/acsmedchemlett.1c00540. eCollection 2021 Dec 9. ACS Med Chem Lett. 2021. PMID: 34917261 Free PMC article.
Phosphatidylserine-Targeting Monoclonal Antibodies Exhibit Distinct Biochemical and Cellular Effects on Anti-CD3/CD28-Stimulated T Cell IFN-γ and TNF-α Production.
Calianese D, Kreiss T, Kasikara C, Davra V, Lahey KC, Gadiyar V, Geng K, Singh S, Honnen W, Jaijyan DK, Reichman C, Siekierka J, Gennaro ML, Kotenko SV, Ucker DS, Brekken RA, Pinter A, Birge RB, Choudhary A. Calianese D, et al. Among authors: siekierka j. J Immunol. 2021 Jul 15;207(2):436-448. doi: 10.4049/jimmunol.2000763. Epub 2021 Jul 2. J Immunol. 2021. PMID: 34215655
Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis.
Tummalapalli SR, Bhat R, Chojnowski A, Prorok M, Kreiss T, Goldberg R, Canan S, Hawryluk N, Mortensen D, Khetani V, Zeldis J, Siekierka JJ, Rotella DP. Tummalapalli SR, et al. Among authors: siekierka jj. ACS Med Chem Lett. 2018 Feb 9;9(3):210-214. doi: 10.1021/acsmedchemlett.7b00477. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541362 Free PMC article.
77 results