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First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development.
Jonas O, Calligaris D, Methuku KR, Poe MM, Francois JP, Tranghese F, Changelian A, Sieghart W, Ernst M, Krummel DA, Cook JM, Pomeroy SL, Cima M, Agar NY, Langer R, Sengupta S. Jonas O, et al. Among authors: sieghart w. J Biomed Nanotechnol. 2016 Jun;12(6):1297-302. doi: 10.1166/jbn.2016.2262. J Biomed Nanotechnol. 2016. PMID: 27319222 Free PMC article.
Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.
Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM. Obradović ALj, et al. Among authors: sieghart w. Brain Res. 2014 Mar 20;1554:36-48. doi: 10.1016/j.brainres.2014.01.036. Epub 2014 Jan 25. Brain Res. 2014. PMID: 24472579 Free PMC article.
8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABAA Receptor.
Golani LK, Platt DM, Rüedi-Bettschen D, Edwanker C, Huang S, Poe MM, Furtmüller R, Sieghart W, Cook JM, Rowlett JK. Golani LK, et al. Among authors: sieghart w. Front Pharmacol. 2021 Apr 20;12:625233. doi: 10.3389/fphar.2021.625233. eCollection 2021. Front Pharmacol. 2021. PMID: 33959005 Free PMC article.
Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes.
Namjoshi OA, Wang ZJ, Rallapalli SK, Johnson EM Jr, Johnson YT, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM. Namjoshi OA, et al. Among authors: sieghart w. Bioorg Med Chem. 2013 Jan 1;21(1):93-101. doi: 10.1016/j.bmc.2012.10.057. Epub 2012 Nov 15. Bioorg Med Chem. 2013. PMID: 23218469 Free PMC article.
368 results