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Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity.
Chen YQ, Yang Y, Zhen EY, Beyer TP, Li H, Wen Y, Ehsani M, Jackson N, Xie K, Jung H, Scheithauer JL, Kumari A, Birrane G, Russell AM, Balasubramaniam D, Liao Z, Siegel RW, Qian Y, Ploug M, Young SG, Konrad RJ. Chen YQ, et al. Among authors: siegel rw. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2322332121. doi: 10.1073/pnas.2322332121. Epub 2024 Apr 16. Proc Natl Acad Sci U S A. 2024. PMID: 38625948
The HLA class I immunopeptidomes of AAV capsid proteins.
Brito-Sierra CA, Lannan MB, Malherbe LP, Siegel RW. Brito-Sierra CA, et al. Among authors: siegel rw. Front Immunol. 2023 Aug 16;14:1212136. doi: 10.3389/fimmu.2023.1212136. eCollection 2023. Front Immunol. 2023. PMID: 37662941 Free PMC article.
The HLA class-II immunopeptidomes of AAV capsids proteins.
Brito-Sierra CA, Lannan MB, Siegel RW, Malherbe LP. Brito-Sierra CA, et al. Among authors: siegel rw. Front Immunol. 2022 Dec 20;13:1067399. doi: 10.3389/fimmu.2022.1067399. eCollection 2022. Front Immunol. 2022. PMID: 36605211 Free PMC article.
LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants.
Westendorf K, Žentelis S, Wang L, Foster D, Vaillancourt P, Wiggin M, Lovett E, van der Lee R, Hendle J, Pustilnik A, Sauder JM, Kraft L, Hwang Y, Siegel RW, Chen J, Heinz BA, Higgs RE, Kallewaard NL, Jepson K, Goya R, Smith MA, Collins DW, Pellacani D, Xiang P, de Puyraimond V, Ricicova M, Devorkin L, Pritchard C, O'Neill A, Dalal K, Panwar P, Dhupar H, Garces FA, Cohen CA, Dye JM, Huie KE, Badger CV, Kobasa D, Audet J, Freitas JJ, Hassanali S, Hughes I, Munoz L, Palma HC, Ramamurthy B, Cross RW, Geisbert TW, Menachery V, Lokugamage K, Borisevich V, Lanz I, Anderson L, Sipahimalani P, Corbett KS, Yang ES, Zhang Y, Shi W, Zhou T, Choe M, Misasi J, Kwong PD, Sullivan NJ, Graham BS, Fernandez TL, Hansen CL, Falconer E, Mascola JR, Jones BE, Barnhart BC. Westendorf K, et al. Among authors: siegel rw. Cell Rep. 2022 May 17;39(7):110812. doi: 10.1016/j.celrep.2022.110812. Epub 2022 Apr 25. Cell Rep. 2022. PMID: 35568025 Free PMC article.
An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif.
Balasubramaniam D, Schroeder O, Russell AM, Fitchett JR, Austin AK, Beyer TP, Chen YQ, Day JW, Ehsani M, Heng AR, Zhen EY, Davies J, Glaesner W, Jones BE, Siegel RW, Qian YW, Konrad RJ. Balasubramaniam D, et al. Among authors: siegel rw. J Lipid Res. 2022 May;63(5):100198. doi: 10.1016/j.jlr.2022.100198. Epub 2022 Mar 17. J Lipid Res. 2022. PMID: 35307397 Free PMC article.
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