Siegel R - Search Results

1

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.

Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X. Emmerson PJ, et al. Among authors: siegel r. Nat Med. 2017 Oct;23(10):1215-1219. doi: 10.1038/nm.4393. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846098

2

Dual-monoclonal, sandwich immunoassay specific for glucose-dependent insulinotropic peptide1-42, the active form of the incretin hormone.

Troutt JS, Siegel RW, Chen J, Sloan JH, Deeg MA, Cao G, Konrad RJ. Troutt JS, et al. Clin Chem. 2011 Jun;57(6):849-55. doi: 10.1373/clinchem.2010.159954. Epub 2011 Apr 22. Clin Chem. 2011. PMID: 21515744

3

A novel, high-sensitivity and drug-tolerant sandwich immunoassay for the quantitative measurement of circulating proteins.

Sloan JH, Ackermann BL, Carpenter JW, Nguyen HT, Stopa K, Siegel RW, Konrad RJ. Sloan JH, et al. Bioanalysis. 2012 Feb;4(3):241-8. doi: 10.4155/bio.11.312. Bioanalysis. 2012. PMID: 22303828

4

A novel high-sensitivity electrochemiluminescence (ECL) sandwich immunoassay for the specific quantitative measurement of plasma glucagon.

Sloan JH, Siegel RW, Ivanova-Cox YT, Watson DE, Deeg MA, Konrad RJ. Sloan JH, et al. Clin Biochem. 2012 Dec;45(18):1640-4. doi: 10.1016/j.clinbiochem.2012.07.111. Epub 2012 Aug 4. Clin Biochem. 2012. PMID: 22890005

5

Novel sandwich immunoassays for the measurement of total and active FGF21.

Umberger TS, Sloan JH, Chen J, Cheng C, Siegel RW, Qian Y, Troutt JS, Konrad RJ. Umberger TS, et al. Bioanalysis. 2014;6(24):3283-93. doi: 10.4155/bio.14.241. Bioanalysis. 2014. PMID: 25534786

6

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids.

Chen YQ, Pottanat TG, Siegel RW, Ehsani M, Qian YW, Zhen EY, Regmi A, Roell WC, Guo H, Luo MJ, Gimeno RE, Van't Hooft F, Konrad RJ. Chen YQ, et al. J Lipid Res. 2020 Aug;61(8):1203-1220. doi: 10.1194/jlr.RA120000781. Epub 2020 Jun 2. J Lipid Res. 2020. PMID: 32487544 Free PMC article.

7

Development and validation of a novel immunogenicity assay to detect anti-drug and anti-PEG antibodies simultaneously with high sensitivity.

Bivi N, Swearingen CA, Shockley TE, Sloan JH, Pottanat TG, Carter QL, Hodsdon ME, Siegel RW, Konrad RJ. Bivi N, et al. J Immunol Methods. 2020 Nov;486:112856. doi: 10.1016/j.jim.2020.112856. Epub 2020 Sep 9. J Immunol Methods. 2020. PMID: 32916164

8

Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure.

Verdino P, Lee SL, Cooper FN, Cottle SR, Grealish PF, Hu CC, Meyer CM, Lin J, Copeland V, Porter G, Schroeder RL, Thompson TD, Porras LL, Dey A, Zhang HY, Beebe EC, Matkovich SJ, Coskun T, Balciunas AM, Ferrante A, Siegel R, Malherbe L, Bivi N, Paavola CD, Hansen RJ, Abernathy MM, Nwosu SO, Carr MC, Heuer JG, Wang X. Verdino P, et al. Among authors: siegel r. Br J Pharmacol. 2023 Aug;180(15):1965-1980. doi: 10.1111/bph.16055. Epub 2023 Mar 8. Br J Pharmacol. 2023. PMID: 36780899

9

A Monovalent Fab Affinity-Capture and Elution Bridging Immunoassay Overcomes Rheumatoid Factor Interference while Accurately Detecting Antidrug Antibodies.

Calderon B, Reynolds NA, Swearingen CA, Carter QL, Bivi N, Cramer JW, Alexander CL, Siegel RW, Konrad RJ. Calderon B, et al. J Appl Lab Med. 2023 Sep 7;8(5):896-908. doi: 10.1093/jalm/jfad035. J Appl Lab Med. 2023. PMID: 37473444

10

Investigation of pre-existing reactivity to biotherapeutics can uncover potential immunogenic epitopes and predict immunogenicity risk.

Bivi N, Moore T, Rodgers G, Denning H, Shockley T, Swearingen CA, Gelfanova V, Calderon B, Peterson DA, Hodsdon ME, Siegel RW, Higgs RE, Konrad RJ. Bivi N, et al. MAbs. 2019 Jul;11(5):861-869. doi: 10.1080/19420862.2019.1612699. Epub 2019 May 17. MAbs. 2019. PMID: 31099718 Free PMC article.

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