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165 results

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Metabolic Profiles Associated With Metformin Efficacy in Cancer.
Andrzejewski S, Siegel PM, St-Pierre J. Andrzejewski S, et al. Among authors: siegel pm. Front Endocrinol (Lausanne). 2018 Aug 21;9:372. doi: 10.3389/fendo.2018.00372. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 30186229 Free PMC article. Review.
PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer.
Dupuy F, Tabariès S, Andrzejewski S, Dong Z, Blagih J, Annis MG, Omeroglu A, Gao D, Leung S, Amir E, Clemons M, Aguilar-Mahecha A, Basik M, Vincent EE, St-Pierre J, Jones RG, Siegel PM. Dupuy F, et al. Among authors: siegel pm. Cell Metab. 2015 Oct 6;22(4):577-89. doi: 10.1016/j.cmet.2015.08.007. Epub 2015 Sep 10. Cell Metab. 2015. PMID: 26365179 Free article.
Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.
Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I. Hulea L, et al. Cell Metab. 2018 Dec 4;28(6):817-832.e8. doi: 10.1016/j.cmet.2018.09.001. Epub 2018 Sep 20. Cell Metab. 2018. PMID: 30244971 Free PMC article.
Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis.
Hsu BE, Tabariès S, Johnson RM, Andrzejewski S, Senecal J, Lehuédé C, Annis MG, Ma EH, Völs S, Ramsay L, Froment R, Monast A, Watson IR, Granot Z, Jones RG, St-Pierre J, Siegel PM. Hsu BE, et al. Among authors: siegel pm. Cell Rep. 2019 Jun 25;27(13):3902-3915.e6. doi: 10.1016/j.celrep.2019.05.091. Cell Rep. 2019. PMID: 31242422 Free article.
STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer.
Totten SP, Im YK, Cepeda Cañedo E, Najyb O, Nguyen A, Hébert S, Ahn R, Lewis K, Lebeau B, La Selva R, Sabourin V, Martínez C, Savage P, Kuasne H, Avizonis D, Santos Martínez N, Chabot C, Aguilar-Mahecha A, Goulet ML, Dankner M, Witcher M, Petrecca K, Basik M, Pollak M, Topisirovic I, Lin R, Siegel PM, Kleinman CL, Park M, St-Pierre J, Ursini-Siegel J. Totten SP, et al. Among authors: siegel pm. Nat Commun. 2021 Jun 3;12(1):3299. doi: 10.1038/s41467-021-23396-2. Nat Commun. 2021. PMID: 34083537 Free PMC article.
HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin.
Biondini M, Kiepas A, El-Houjeiri L, Annis MG, Hsu BE, Fortier AM, Morin G, Martina JA, Sirois I, Aguilar-Mahecha A, Gruosso T, McGuirk S, Rose AAN, Tokat UM, Johnson RM, Sahin O, Bareke E, St-Pierre J, Park M, Basik M, Majewski J, Puertollano R, Pause A, Huang S, Keler T, Siegel PM. Biondini M, et al. Among authors: siegel pm. Oncogene. 2022 Mar;41(12):1701-1717. doi: 10.1038/s41388-022-02206-z. Epub 2022 Feb 2. Oncogene. 2022. PMID: 35110681
p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress.
Lewis K, La Selva R, Maldonado E, Annis MG, Najyb O, Cepeda Cañedo E, Totten S, Hébert S, Sabourin V, Mirabelli C, Ciccolini E, Lehuédé C, Choinière L, Russo M, Avizonis D, Park M, St-Pierre J, Kleinman CL, Siegel PM, Ursini-Siegel J. Lewis K, et al. Among authors: siegel pm. Redox Biol. 2024 Apr;70:103028. doi: 10.1016/j.redox.2024.103028. Epub 2024 Jan 5. Redox Biol. 2024. PMID: 38211442 Free PMC article.
Antibody-mediated targeting of Claudins in cancer.
Vonniessen B, Tabariès S, Siegel PM. Vonniessen B, et al. Among authors: siegel pm. Front Oncol. 2024 Feb 2;14:1320766. doi: 10.3389/fonc.2024.1320766. eCollection 2024. Front Oncol. 2024. PMID: 38371623 Free PMC article. Review.
165 results