Siegal G - Search Results

1

Interrogating the Essential Bacterial Cell Division Protein FtsQ with Fragments Using Target Immobilized NMR Screening (TINS).

Glas M, Ab E, Hollander J, Siegal G, Luirink J, de Esch I. Glas M, et al. Among authors: siegal g. Int J Mol Sci. 2019 Jul 27;20(15):3684. doi: 10.3390/ijms20153684. Int J Mol Sci. 2019. PMID: 31357624 Free PMC article.

2

Target immobilization and NMR screening of fragments in early drug discovery.

Siegal G, Hollander JG. Siegal G, et al. Curr Top Med Chem. 2009;9(18):1736-45. doi: 10.2174/156802609790102400. Curr Top Med Chem. 2009. PMID: 19929836

3

Target immobilization as a strategy for NMR-based fragment screening: comparison of TINS, STD, and SPR for fragment hit identification.

Kobayashi M, Retra K, Figaroa F, Hollander JG, Ab E, Heetebrij RJ, Irth H, Siegal G. Kobayashi M, et al. Among authors: siegal g. J Biomol Screen. 2010 Sep;15(8):978-89. doi: 10.1177/1087057110375614. J Biomol Screen. 2010. PMID: 20817886

4

TINS, target immobilized NMR screening: an efficient and sensitive method for ligand discovery.

Vanwetswinkel S, Heetebrij RJ, van Duynhoven J, Hollander JG, Filippov DV, Hajduk PJ, Siegal G. Vanwetswinkel S, et al. Among authors: siegal g. Chem Biol. 2005 Feb;12(2):207-16. doi: 10.1016/j.chembiol.2004.12.004. Chem Biol. 2005. PMID: 15734648

5

Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB.

Früh V, Zhou Y, Chen D, Loch C, Ab E, Grinkova YN, Verheij H, Sligar SG, Bushweller JH, Siegal G. Früh V, et al. Among authors: siegal g. Chem Biol. 2010 Aug 27;17(8):881-91. doi: 10.1016/j.chembiol.2010.06.011. Chem Biol. 2010. PMID: 20797617 Free PMC article.

6

NMR in structure-based drug design.

Carneiro MG, Ab E, Theisgen S, Siegal G. Carneiro MG, et al. Among authors: siegal g. Essays Biochem. 2017 Nov 8;61(5):485-493. doi: 10.1042/EBC20170037. Print 2017 Nov 8. Essays Biochem. 2017. PMID: 29118095 Review.

7

NMR in target driven drug discovery: why not?

Keiffer S, Carneiro MG, Hollander J, Kobayashi M, Pogoryelev D, Ab E, Theisgen S, Müller G, Siegal G. Keiffer S, et al. Among authors: siegal g. J Biomol NMR. 2020 Nov;74(10-11):521-529. doi: 10.1007/s10858-020-00343-9. Epub 2020 Sep 8. J Biomol NMR. 2020. PMID: 32901320 Free PMC article.

8

Fragment-derived modulators of an industrial β-glucosidase.

Makraki E, Darby JF, Carneiro MG, Firth JD, Heyam A, Ab E, O'Brien P, Siegal G, Hubbard RE. Makraki E, et al. Among authors: siegal g. Biochem J. 2020 Nov 27;477(22):4383-4395. doi: 10.1042/BCJ20200507. Biochem J. 2020. PMID: 33111951 Free PMC article.

9

Rapid protein-ligand costructures from sparse NOE data.

Shah DM, A B E, Diercks T, Hass MA, van Nuland NA, Siegal G. Shah DM, et al. Among authors: siegal g. J Med Chem. 2012 Dec 13;55(23):10786-90. doi: 10.1021/jm301396d. Epub 2012 Nov 19. J Med Chem. 2012. PMID: 23145792

10

Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory.

Pritišanac I, Degiacomi MT, Alderson TR, Carneiro MG, Ab E, Siegal G, Baldwin AJ. Pritišanac I, et al. Among authors: siegal g. J Am Chem Soc. 2017 Jul 19;139(28):9523-9533. doi: 10.1021/jacs.6b11358. Epub 2017 Jul 10. J Am Chem Soc. 2017. PMID: 28691806

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