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Signalling to eIF4E in cancer.
Siddiqui N, Sonenberg N. Siddiqui N, et al. Biochem Soc Trans. 2015 Oct;43(5):763-72. doi: 10.1042/BST20150126. Biochem Soc Trans. 2015. PMID: 26517881 Free PMC article. Review.
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N. Morita M, et al. Among authors: siddiqui n. Mol Cell Biol. 2012 Sep;32(17):3585-93. doi: 10.1128/MCB.00455-12. Epub 2012 Jul 2. Mol Cell Biol. 2012. PMID: 22751931 Free PMC article.
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies.
Alain T, Morita M, Fonseca BD, Yanagiya A, Siddiqui N, Bhat M, Zammit D, Marcus V, Metrakos P, Voyer LA, Gandin V, Liu Y, Topisirovic I, Sonenberg N. Alain T, et al. Among authors: siddiqui n. Cancer Res. 2012 Dec 15;72(24):6468-76. doi: 10.1158/0008-5472.CAN-12-2395. Epub 2012 Oct 24. Cancer Res. 2012. PMID: 23100465
Proposing a mechanism of action for ataluren.
Siddiqui N, Sonenberg N. Siddiqui N, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12353-12355. doi: 10.1073/pnas.1615548113. Epub 2016 Oct 19. Proc Natl Acad Sci U S A. 2016. PMID: 27791186 Free PMC article. No abstract available.
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.
Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, Pearl D, Siddiqui N, Strack S, McGuirk S, St-Pierre J, Larsson O, Topisirovic I, Vali H, McBride HM, Bergeron JJ, Sonenberg N. Morita M, et al. Among authors: siddiqui n. Mol Cell. 2017 Sep 21;67(6):922-935.e5. doi: 10.1016/j.molcel.2017.08.013. Epub 2017 Sep 14. Mol Cell. 2017. PMID: 28918902 Free article.
4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold.
Sharma V, Sood R, Lou D, Hung TY, Lévesque M, Han Y, Levett JY, Wang P, Murthy S, Tansley S, Wang S, Siddiqui N, Tahmasebi S, Rosenblum K, Avoli M, Lacaille JC, Sonenberg N, Khoutorsky A. Sharma V, et al. Among authors: siddiqui n. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2025522118. doi: 10.1073/pnas.2025522118. Proc Natl Acad Sci U S A. 2021. PMID: 33876772 Free PMC article.
Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase.
Kozlov G, De Crescenzo G, Lim NS, Siddiqui N, Fantus D, Kahvejian A, Trempe JF, Elias D, Ekiel I, Sonenberg N, O'Connor-McCourt M, Gehring K. Kozlov G, et al. Among authors: siddiqui n. EMBO J. 2004 Jan 28;23(2):272-81. doi: 10.1038/sj.emboj.7600048. Epub 2003 Dec 18. EMBO J. 2004. PMID: 14685257 Free PMC article.
1,080 results