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Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Nat Commun. 2023 Aug 9;14(1):4812. doi: 10.1038/s41467-023-40536-y.
Nat Commun. 2023.
PMID: 37558654
Free PMC article.
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Bollinger E, Peloquin M, Libera J, Albuquerque B, Pashos E, Shipstone A, Hadjipanayis A, Sun Z, Xing G, Clasquin M, Stansfield JC, Tierney B, Gernhardt S, Siddall CP, Greizer T, Geoly FJ, Vargas SR, Gao LC, Williams G, Marshall M, Rosado A, Steppan C, Filipski KJ, Zhang BB, Miller RA, Roth Flach RJ.
Bollinger E, et al. Among authors: siddall cp.
Mol Metab. 2022 Dec;66:101611. doi: 10.1016/j.molmet.2022.101611. Epub 2022 Oct 8.
Mol Metab. 2022.
PMID: 36220546
Free PMC article.
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A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance.
Jun LS, Siddall CP, Rosen ED.
Jun LS, et al. Among authors: siddall cp.
Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E825-35. doi: 10.1152/ajpendo.00147.2011. Epub 2011 Jul 19.
Am J Physiol Endocrinol Metab. 2011.
PMID: 21771968
Free PMC article.
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Simvastatin inhibits Staphylococcus aureus host cell invasion through modulation of isoprenoid intermediates.
Horn MP, Knecht SM, Rushing FL, Birdsong J, Siddall CP, Johnson CM, Abraham TN, Brown A, Volk CB, Gammon K, Bishop DL, McKillip JL, McDowell SA.
Horn MP, et al. Among authors: siddall cp.
J Pharmacol Exp Ther. 2008 Jul;326(1):135-43. doi: 10.1124/jpet.108.137927. Epub 2008 Apr 3.
J Pharmacol Exp Ther. 2008.
PMID: 18388257
Free PMC article.
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