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Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST.
Schaefer IM, Hemming ML, Lundberg MZ, Serrata MP, Goldaracena I, Liu N, Yin P, Paulo JA, Gygi SP, George S, Morgan JA, Bertagnolli MM, Sicinska ET, Chu C, Zheng S, Mariño-Enríquez A, Hornick JL, Raut CP, Ou WB, Demetri GD, Saka SK, Fletcher JA. Schaefer IM, et al. Among authors: sicinska et. Br J Cancer. 2022 Nov;127(11):2072-2085. doi: 10.1038/s41416-022-01990-5. Epub 2022 Sep 29. Br J Cancer. 2022. PMID: 36175617 Free PMC article.
Aberrant AKT activation drives well-differentiated liposarcoma.
Gutierrez A, Snyder EL, Marino-Enriquez A, Zhang YX, Sioletic S, Kozakewich E, Grebliunaite R, Ou WB, Sicinska E, Raut CP, Demetri GD, Perez-Atayde AR, Wagner AJ, Fletcher JA, Fletcher CD, Look AT. Gutierrez A, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16386-91. doi: 10.1073/pnas.1106127108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930930 Free PMC article.
Genome-wide functional screening identifies CDC37 as a crucial HSP90-cofactor for KIT oncogenic expression in gastrointestinal stromal tumors.
Mariño-Enríquez A, Ou WB, Cowley G, Luo B, Jonker AH, Mayeda M, Okamoto M, Eilers G, Czaplinski JT, Sicinska E, Wang Y, Taguchi T, Demetri GD, Root DE, Fletcher JA. Mariño-Enríquez A, et al. Oncogene. 2014 Apr 3;33(14):1872-6. doi: 10.1038/onc.2013.127. Epub 2013 Apr 15. Oncogene. 2014. PMID: 23584476 Free PMC article.
Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma.
Nakayama R, Zhang YX, Czaplinski JT, Anatone AJ, Sicinska ET, Fletcher JA, Demetri GD, Wagner AJ. Nakayama R, et al. Among authors: sicinska et. Oncotarget. 2016 Mar 29;7(13):16581-92. doi: 10.18632/oncotarget.7667. Oncotarget. 2016. PMID: 26918731 Free PMC article.
MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation.
Schaefer IM, Wang Y, Liang CW, Bahri N, Quattrone A, Doyle L, Mariño-Enríquez A, Lauria A, Zhu M, Debiec-Rychter M, Grunewald S, Hechtman JF, Dufresne A, Antonescu CR, Beadling C, Sicinska ET, van de Rijn M, Demetri GD, Ladanyi M, Corless CL, Heinrich MC, Raut CP, Bauer S, Fletcher JA. Schaefer IM, et al. Among authors: sicinska et. Nat Commun. 2017 Mar 8;8:14674. doi: 10.1038/ncomms14674. Nat Commun. 2017. PMID: 28270683 Free PMC article.
63 results