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Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.
Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Zhao N, et al. Among authors: sicheri f. J Clin Invest. 2018 Apr 2;128(4):1283-1299. doi: 10.1172/JCI95873. Epub 2018 Feb 26. J Clin Invest. 2018. PMID: 29480818 Free PMC article.
Principles of IRE1 modulation using chemical tools.
Lee KP, Sicheri F. Lee KP, et al. Among authors: sicheri f. Methods Enzymol. 2011;490:271-94. doi: 10.1016/B978-0-12-385114-7.00016-7. Methods Enzymol. 2011. PMID: 21266256
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.
Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, Sicheri F, Patterson JB. Volkmann K, et al. Among authors: sicheri f. J Biol Chem. 2011 Apr 8;286(14):12743-55. doi: 10.1074/jbc.M110.199737. Epub 2011 Feb 8. J Biol Chem. 2011. PMID: 21303903 Free PMC article.
Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F. Sanches M, et al. Among authors: sicheri f. Nat Commun. 2014 Aug 28;5:4202. doi: 10.1038/ncomms5202. Nat Commun. 2014. PMID: 25164867 Free PMC article.
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.
Banerjee S, Gusho E, Gaughan C, Dong B, Gu X, Holvey-Bates E, Talukdar M, Li Y, Weiss SR, Sicheri F, Saunthararajah Y, Stark GR, Silverman RH. Banerjee S, et al. Among authors: sicheri f. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5071-5076. doi: 10.1073/pnas.1815071116. Epub 2019 Feb 27. Proc Natl Acad Sci U S A. 2019. PMID: 30814222 Free PMC article.
A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency.
Daou S, Talukdar M, Tang J, Dong B, Banerjee S, Li Y, Duffy NM, Ogunjimi AA, Gaughan C, Jha BK, Gish G, Tavernier N, Mao D, Weiss SR, Huang H, Silverman RH, Sicheri F. Daou S, et al. Among authors: sicheri f. Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):24802-24812. doi: 10.1073/pnas.2006883117. Epub 2020 Sep 21. Proc Natl Acad Sci U S A. 2020. PMID: 32958664 Free PMC article.
Putting the brakes on the unfolded protein response.
Sicheri F, Silverman RH. Sicheri F, et al. J Cell Biol. 2011 Apr 4;193(1):17-9. doi: 10.1083/jcb.201101105. Epub 2011 Mar 28. J Cell Biol. 2011. PMID: 21444688 Free PMC article.
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Gaughan C, Brinton MA, Perelygin AA, Kourinov I, Guarné A, Silverman RH, Sicheri F. Huang H, et al. Among authors: sicheri f. Mol Cell. 2014 Jan 23;53(2):221-34. doi: 10.1016/j.molcel.2013.12.025. Mol Cell. 2014. PMID: 24462203 Free PMC article.
MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
Couzens AL, Xiong S, Knight JDR, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F, Gingras AC. Couzens AL, et al. Among authors: sicheri f. Mol Cell Proteomics. 2017 Jun;16(6):1098-1110. doi: 10.1074/mcp.M116.065490. Epub 2017 Apr 3. Mol Cell Proteomics. 2017. PMID: 28373298 Free PMC article.
158 results