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Identification of key residues of the DNA glycosylase OGG1 controlling efficient DNA sampling and recruitment to oxidized bases in living cells.
D'Augustin O, Gaudon V, Siberchicot C, Smith R, Chapuis C, Depagne J, Veaute X, Busso D, Di Guilmi AM, Castaing B, Radicella JP, Campalans A, Huet S. D'Augustin O, et al. Among authors: siberchicot c. Nucleic Acids Res. 2023 Jun 9;51(10):4942-4958. doi: 10.1093/nar/gkad243. Nucleic Acids Res. 2023. PMID: 37021552 Free PMC article.
A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner.
Ragu S, Droin N, Matos-Rodrigues G, Barascu A, Caillat S, Zarkovic G, Siberchicot C, Dardillac E, Gelot C, Guirouilh-Barbat J, Radicella JP, Ishchenko AA, Ravanat JL, Solary E, Lopez BS. Ragu S, et al. Among authors: siberchicot c. Cell Death Differ. 2023 May;30(5):1349-1365. doi: 10.1038/s41418-023-01141-0. Epub 2023 Mar 3. Cell Death Differ. 2023. PMID: 36869180 Free PMC article.
OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression.
Tanushi X, Pinna G, Vandamme M, Siberchicot C, D'Augustin O, Di Guilmi AM, Radicella JP, Castaing B, Smith R, Huet S, Leteurtre F, Campalans A. Tanushi X, et al. Among authors: siberchicot c. Front Cell Dev Biol. 2023 Feb 3;11:1124960. doi: 10.3389/fcell.2023.1124960. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 36819096 Free PMC article.
Loss of CD24 promotes radiation‑ and chemo‑resistance by inducing stemness properties associated with a hybrid E/M state in breast cancer cells.
Bontemps I, Lallemand C, Biard D, Dechamps N, Kortulewski T, Bourneuf E, Siberchicot C, Boussin F, Chevillard S, Campalans A, Lebeau J. Bontemps I, et al. Among authors: siberchicot c. Oncol Rep. 2023 Jan;49(1):4. doi: 10.3892/or.2022.8441. Epub 2022 Nov 11. Oncol Rep. 2023. PMID: 36367190 Free PMC article.