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The amino-terminal immunoglobulin-like domain of activated leukocyte cell adhesion molecule binds specifically to the membrane-proximal scavenger receptor cysteine-rich domain of CD6 with a 1:1 stoichiometry.
Bowen MA, Bajorath J, Siadak AW, Modrell B, Malacko AR, Marquardt H, Nadler SG, Aruffo A. Bowen MA, et al. Among authors: siadak aw. J Biol Chem. 1996 Jul 19;271(29):17390-6. doi: 10.1074/jbc.271.29.17390. J Biol Chem. 1996. PMID: 8663238 Free article.
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.
Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny J, Siadak AW, Brown TJ, Emswiler J, Raecho H, Larsen CP, Pearson TC, Ledbetter JA, Aruffo A, Mittler RS. Shuford WW, et al. Among authors: siadak aw. J Exp Med. 1997 Jul 7;186(1):47-55. doi: 10.1084/jem.186.1.47. J Exp Med. 1997. PMID: 9206996 Free PMC article.
Anti-CD40 therapy extends renal allograft survival in rhesus macaques.
Pearson TC, Trambley J, Odom K, Anderson DC, Cowan S, Bray R, Lin A, Hollenbaugh D, Aruffo A, Siadak AW, Strobert E, Hennigar R, Larsen CP. Pearson TC, et al. Among authors: siadak aw. Transplantation. 2002 Oct 15;74(7):933-40. doi: 10.1097/00007890-200210150-00006. Transplantation. 2002. PMID: 12394833
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